Original research
Bar-Nur O, Russ HA, Efrat S, Benvenisty N (2011) Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 9:17-23.
Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, Toren G, Farhy C, Pasmanik-Chor M, Oron-Karni V, Ravassard P, Efrat S (2011) Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One 6: e25566.
Bar Y, Russ HA, Anker-Kitai L, Knoller S, Efrat S (2012) Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J Biol Chem 287:17269-17280.
Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T (2012) Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic beta-cell fate in response to cytokines. Cell Metab 16:449-461.
Lenz A, Toren-Haritan G, Efrat S (2014) Redifferentiation of adult human β cells expanded in vitro by inhibition of the WNT pathway. PLoS One 9:e112914.
Nathan G, Kredo-Russo S, Geiger T, Lenz A, Kaspi H, Hornstein E, Efrat S (2015) miR-375 promotes redifferentiation of adult human β cells expanded in vitro. PLoS One 10: e0122108.
Sintov E, Nathan G, Knoller S, Pasmanik-Chor M, Russ HA, Efrat S (2015) Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro. Sci Rep 5:13024.
Toren-Haritan G, Efrat S (2015) TGFβ pathway inhibition redifferentiates human pancreatic islet β cells expanded in vitro. PLoS One 10: e0139168.
Friedman-Mazursky O, Elkon R, Efrat S (2016) Redifferentiation of human islet β cells expanded in vitro by inhibition of ARX. Sci Rep 6:20698.
Thurner M, Shenhav L, Wesolowska-Andersen A, Bennett AJ, Barrett A, Gloyn AL, McCarthy MI, Beer NL, Efrat S (2017) Genes associated with pancreas development and function maintain open chromatin structure in iPSCs generated from human pancreatic beta cells. Stem Cell Rep 9:1395–1405.
Reviews
Russ HA, Efrat S (2011) In-vivo functional assessment of engineered human insulin-producing cells. In Cell Transplantation, Soto-Gutierrez A, Navarro-Alvarez N, Fox IJ (eds.), Methods in Bioengineering, Yarmush ML, Langer RS (eds.), Artech House, pp. 35-46.
Russ HA, Efrat S (2011) Development of human insulin-producing cells for cell therapy of diabetes. Ped Endocrinol Rev 9:590-597.
Efrat S, Russ HA (2012) Making beta cells from adult tissues. Trends Endocrinol Metab 23:278-285.
Efrat S (2013) Recent progress in generation of human surrogate beta cells. Curr Opin Endocrinol Diab Obes 20:259-264.
Bar Y, Efrat S (2014) The Notch pathway in beta-cell growth and differentiation. In The Pancreatic Beta Cell, Litwack G (ed.), Vitamins and Hormones vol. 95, Academic Press/Elsevier, pp. 391-405.
Efrat S (2016) Mechanisms of adult human β-cell in-vitro dedifferentiation and redifferentiation. Diabetes Obes Metab 18 (Suppl. 1): 97–101.
Efrat S (2019) Beta-cell dedifferentiation in type 2 diabetes. Stem Cells 37:1267-1272.
Grants
2011-2014 Insulin-producing cells from iPS cells derived from human beta cells. Juvenile Diabetes Research Foundation International
2011-2014 Beta-cell replacement by human islet beta cells expanded in vitro. Israel Science Foundation
2012-2018 Stem cells for biological assays of novel drugs and predictive toxicology. Innovative Medicines Initiative
2013-2015 Redifferentiation of expanded human beta-cell-derived cells for cell therapy of diabetes. Israel Ministry of Industry, Trade, and Labor Kamin Program
2013-2016 Generation of human insulin-producing cells by redifferentiation of cells expanded from pancreatic islet beta cells through inhibition of the NOTCH pathway. Israel Science Foundation
2015-2017 Graft survival and function of hESC-derived islet-like cells. Kadimastem Ltd.
2015-2018 Generation of human insulin-producing cells for cell replacement therapy of diabetes. Rosetrees Trust
2017-2018 Transdifferentiation of MSCs into insulin-producing cells. Association for Advancement of Novel Therapies for Malignancies and Transplantation
2020 Development of diabetes cell replacement therapy. Grodman Cure Foundation
