BA, 1985, Yeshiva University, NY, USA
PhD, 1995, Columbia University, NY, USA
post-doctoral fellowship, 1995-99, Yale University, New Haven, USA
BA, 1985, Yeshiva University, NY, USA
PhD, 1995, Columbia University, NY, USA
post-doctoral fellowship, 1995-99, Yale University, New Haven, USA
ביולוגיה מבנית של העברת אותות.
מערכות מולקולריות שאנו חוקרים:
Sachyani, D., Dvir, M., Strulovich, R., Ben-Tal Cohen, E., Tria, G., Tobelaim, W., Peretz, A., Pongs, O., Svergun, D., Attali, B., and J. A. Hirsch. (2014). “Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-terminal Domain in Complex with Calmodulin.” Structure, 22: 1582.
Giladi, M., Michaely, L., Almagor, L., Bar-On, D., Buki, T., Ashery, U., Khananshvili, D. †, and J. A. Hirsch†. (2013). “The C2B Domain Is The Primary Ca2+ Sensor In DOC2B: A Structural And Functional Analysis.” J Mol. Biol., 425: 4629.
Almagor, L., Chomsky-Hecht, O., Ben-Mocha, A., Hendin-Barak, D., Dascal, N., and J. A. Hirsch. (2012). “The Role of a Voltage-dependent Ca2+ Channel Intracellular Linker: A Structure-Function Analysis.” J Neuroscience, 32:7602.
Sasson, Y., Navon-Perry, L., Huppert, D., and J. A. Hirsch. (2011). “RGK Family G-domain-GTP Analog Complex Structures and Nucleotide-binding Properties.” J Mol. Biol., 413:372.
Dessau, M., Halimi, Y., Erez, T., Chomsky-Hecht, O., Chamovitz, D.A., and J. A. Hirsch. (2008). “The Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome Assembly.” The Plant Cell, 20: 2815.
Wiener, R., Haitin, Y., Shamgar, L., Fernandez-Alonso, M.C., Martos, A., Chomsky-Hecht, O., Rivas, G., Attali, B., and J.A. Hirsch. (2008) “The KCNQ1(Kv7.1) COOH-terminus, a Multitiered Scaffold for Subunit Assembly and Protein Interaction.” J Biol. Chem, 283:5815.
Opatowsky, Y., Chen, C-C., Campbell, K. P., and J. A. Hirsch. (2004). “Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core and Its Complex with the Alpha1 Interaction Domain.” Neuron, 42: 387.