פרופ' נפתלי סביון

פרופ' (אמריטוס) לביוכימיה קלינית

החוג לגנטיקה מולקולרית של האדם ולביוכימיה

והמכון לחקר העין ע"ש מוריס וגבריאלה גולדשלגר

מיקום: המכון לחקר העין ע"ש מוריס וגבריאלה גולדשלגר, מרכז רפואי שיבא, תל השומר

השכלה:

1970 – 1973 תואר בוגר בביולוגיה, האוניברסיטה העברית בירושלים 1974 – 1978 תואר דוקטור בביוכימיה (מסלול ישיר), האוניברסיטה העברית בירושלים

1978 – 1981 פוסט-דוקטורט, המכון לחקר הסרטן, אוניברסיטת קליפורניה, סן-פרנסיסקו, ארה"ב

1981 – 1982 פוסט-דוקטורט, המחלקה לאימונולוגיה, הפקולטה לרפואה, האוניברסיטה העברית בירושלים.

מינויים:

1982 – 1985 מרצה, הפקולטה לרפואה, אוניברסיטת תל אביב

1986 – 1990 מרצה בכיר, הפקולטה לרפואה, אוניברסיטת תל אביב

1990 – 1995 פרופ' חבר, הפקולטה לרפואה, אוניברסיטת תל אביב

1991 – 1992 חוקר אורח, הצלב האדום האמריקאי, רוקוויל, מרילנד, ארה"ב

1995 -  2019 פרופ' מן-המניין, הפקולטה לרפואה, אוניברסיטת תל אביב

2019 -           פרופ' אמריטוס, הפקולטה לרפואה, אוניברסיטת תל אביב

פיתוח נגזרת של אליצין (החומר הפעיל בשום) כתרופה המשפעלת את מנגנוני ההגנה התאיים כנגד נגזרות חמצן פעילות – (ROS) הוכחת יעילותה בתרבית רקמה ובחיות מעבדה כטיפול למחלות נוירודגנרטיביות, ניוון רשתית העין וקטרקט, מחלות כלי דם ואוסטיאופורוזיס.

Selected Publications:

• I. Bleichman, S. Hiram-Bab, Y. Gabet, N. Savion. S-Allylmercapto-N-Acetylcysteine (ASSNAC) Attenuates Osteoporosis in Ovariectomized (OVX) Mice. Antioxidants 13:474, 2024. [I.F. 7.0] https://doi.org/10.3390/antiox13040474
• R. Abu-Kheit, S. Kotev-Emeth, S. Hiram-Bab, Y. Gabet, N. Savion. S-Allylmercapto-N-Acetylcysteine protects bone cells from oxidation and improves femur microarchitecture in healthy and diabetic mice. Exp. Biol. Med., 247:1489-1500, 2022. [I.F. 4.08] https://doi.org/10.1177/15353702221095047
• N. Savion, S. Dahamshi, M. Morein, S. Kotev-Emeth.  S-Allylmercapro-N-Acetylcysteine Attenuates the Oxidation-Induced Lens Opacification and Retinal Pigment Epithelial Cell Death In Vitro. Antioxidants, 8:25, 2019. [I.F. 4.520]   10.3390/antiox8010025
• N. Savion, A. Levine, S. Kotev-Emeth, U. Bening Abu-Shach, L. Broday.  S-allylmercapto-N-acetylcysteine protects against oxidative stress and extends lifespan in Caenorhabditis elegans. PLOS One, 13(3):e0194780. 2018.      10.1371/journal.pone.0194780
• Budnik, B. Shenkman, H. Hauschner, I. Zilinsky, N. Savion.  Role of heterotrimeric G proteins in platelet activation and clot formation in platelets treated with integrin αIIbβ3 inhibitor. Platelets, 29(3):265-269, 2017.    (DOI: 10.1080/09537104.2017.1295136)

• D. Ben-Zvi, N. Savion, F. Kolodgie, A. Simon, S. Fisch, K. Schäfer, N. Bachner-Hinenzon, X. Cao, A. Gertler, G. Solomon, E. Kachel, E. Raanani, J. Lavee, S. Kotev Emeth, R. Virmani, F.J. Schoen, J. Schneiderman.  Local application of leptin antagonist attenuates Angiotensin II-induced ascending aortic aneurysm and cardiac remodeling. J. Am. Heart Assoc. 5(5):e003474; 2016. (doi: 10.1161/JAHA.116.003474).
• Budnik, B. Shenkman, N. Savion.  Role of G protein signaling in formation of the fibrin(ogen)–integrin αIIbβ3–actin cytoskeleton complex in platelets. Platelets, 27(6):563-575, 2016.  (DOI: 10.3109/09537104.2016.1147544)
• Budnik, B. Shenkman, N. Savion.  Synergistic effect of signaling from receptors of soluble platelet agonists and outside-in signaling in formation of a stable fibrinogen–integrin αIIbβ3–actin cytoskeleton complex. Thromb. Res. 135:114–120, 2015. (http://dx.doi.org/10.1016/j.thromres.2014.10.005)
• N. Savion, N. Izigov, M. Morein, S. Pri-Chen, S. Kotev-Emeth.  S-Allylmercapto-N-acetylcysteine (ASSNAC) protects cultured nerve cells from oxidative stress and attenuates experimental autoimmune encephalomyelitis. Neurosci. Lett. 583:108-113, 2014. 10.1016/j.neulet.2014.09.034
• I. Ben Aharon, H. Bar Joseph, M. Tzabari, B. Shenkman, N. Farzam, M. Levi, R. Shalgi, S.M. Stemmer, N. Savion. Doxorubicin-induced vascular toxicity - Targeting potential pathways may reduce procoagulant activity. PLos ONE, 8(9): e75157, 2013.      (doi:10.1371/journal.pone.0075157)
• M. Tao, P. Yu, B.T. Nguyen, B. Mizrahi, N. Savion, G. Sukhova, F.D. Kolodgie, R. Virmani, C.K. Ozaki, J. Schneiderman. Locally Applied Leptin Induces Regional Aortic Wall Degeneration in ApoE Deficient Mice Preceding Aneurysm Formation. Arterioscler. Thromb. Vasc. Biol. 33(2):311-20, 2013. (doi:10.1161/ATVBAHA.112.300543.)
• J. Schneiderman, K. Schaefer, F.D. Kolodgie, N. Savion, S. Kotev-Emeth, R. Dardik, A.J. Simon, M. Halak, C. Pariente, I. Engelberg, S. Konstantinides, R. Virmani. Leptin Locally Synthesized in Carotid Atherosclerotic Plaques may be Associated with Lesion Instability and Cerebral Emboli. J. Am. Heart Assoc. September 4, 2012; 1: e001727.      (doi:10.1161/JAHA.112.001727).
• S. Mendelboum Raviv, K. Szekeres-Csiki, A. Jenei, J. Nagy, B. Shenkman, N. Savion, J. Harsfalvi. Coating conditions matter to collagen matrix formation regarding von Willebrand factor and platelet binding. Thromb. Res. 129: e29–e35, 2012.      (doi:10.1016/j.thromres.2011.09.030)
• N. Izigov, N. Farzam, N. Savion. S-allylmercapto-N-acetylcysteine up-regulates cellular glutathione and protects vascular endothelial cells from oxidative stress. Free Radic. Biol. Med. 50: 1131–1139, 2011. (DOI:10.1016/j.freeradbiomed.2011.01.028)
• L. Horev-Azaria, S, Eliav, N. Izigov, S. Pri-Chen, D. Mirelman, T. Miron, A. Rabinkov, M. Wilchek, J. Jacob-Hirsch, N. Amariglio, N. Savion. Allicin Up-Regulates Cellular Glutathione Level in Vascular Endothelial cells. Eur. J. Nutrition, 48: 67-74, 2009.     (DOI:10.1007/s00394-008-0762-3)
• N. Geffen, M. Topaz, L. Kredy-Farhan, I. Barequet, N. Farzam, E.I. Assia, N. Savion. Phacoemulsification-induced injury in corneal endothelial cells is mediated by apoptosis: a novel in-vitro model. J. Cataract Refract. Surg., 34: 2146-2152, 2008.      (DOI:10.1016/j.jcrs.2008.08.024)
• B. Shenkman, S. Matetzky, P. Fefer, H. Hod, Y. Einav, A. Lubetsky, D. Varon, N. Savion. Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests. Thromb. Res., 122: 336-345, 2008.     (DOI:10.1016/j.thromres.2007.10.018)
• S. Pitaru, M. Noff, L. Blok, E. Nir, S. Pitaru, A. Goldlust, N. Savion. Long-term efficacy of a novel ribose-cross-linked collagen dermal filler: A histologic and histomorphometric study in an animal model. Dermatologic Surgery 33(9): 1045-1053: 2007.     (DOI:10.1111/j.1524-4725.2007.33218.x)
• N. Savion, D. Varon. Impact - The Cone and Plate(let) Analyzer: Testing Platelet Function and Anti-Platelet Drug Response. J. Pathophysiol. Haemost. Thromb. 35: 83-88, 2006.     (DOI:10.1159/000093548)
• Y. Porat, S. Porozov, D. Belkin, D. Shimoni, Y. Fisher, A. Belleli, D. Czeiger, W. F. Silverman, M. Belkin, A. Battler, V. Fulga, N. Savion. Isolation of an Adult Blood-Derived Progenitor Cell Population Capable of Differentiation into Angiogenic, Myocardial and Neural Lineages. Brit. J. Haematol. 135: 703-714; 2006. (DOI:10.1111/j.1365-2141.2006.06344.x)
• A. Solpov, B. Shenkman, Y. Vitkovsky, G. Brill, A. Koltakov, N. Farzam, D. Varon, I. Bank, N. Savion. Platelets Enhance CD4+ Lymphocyte Adhesion to Extracellular Matrix under Flow Conditions: Role of Platelet Aggregation, Integrins, and non-Integrin Receptors. Thromb. Haemost. 95: 815-821, 2006.     (DOI:10.1160/TH05-07-0524)
• S. Matetzky, B. Shenkman, V. Guetta, M. Shechter, R. Bienart, I. Goldenberg, I. Novikov, H. Pres, N. Savion, D. Varon, H. Hod. Clopidogrel Resistance Is Associated With Increased Risk of Recurrent Atherothrombotic Events in Patients With Acute Myocardial Infarction. Circulation 109: 3171-3175, 2004. (DOI:10.1161/01.CIR.0000130846.46168.03)
• K. Jurk, K. J. Clemetson, P. G. de Groot, M. F. Brodde, M. Steiner, N. Savion, D. Varon, J. J. Sixma, H. Van Aken, B. E. Kehrel. Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor. FASEB J. 17: U254-U271, 2003. (DOI: 10.1096/fj.02-0830fje)
• S. Kotev-Emeth, S. Pitaru, S. Pri-Chen, N. Savion. Establishment of a rat long-term culture expressing the osteogenic phenotype: dependence on Dexamethasone and FGF-2. Connective Tissue Res, 43: 606-612, 2002.      (DOI:10.1080/03008200290001339)
• N. Savion, B. Shenkman, I. Tamarin, R. Dardik, D. Varon. Transient adhesion refractoriness of platelets under flow conditions: The role of partial activation and microaggregate formation in controlling thrombus expansion. Brit. J. Haematol. 112: 1055-1061, 2001.     (DOI:10.1046/j.1365-2141.2001.02657.x)
• R. Dardik, D. Varon, I. Tamarin, A. Zivelin, O. Salomon, B. Shenkman, N. Savion. Homocysteine and oxidized low density lipoprotein enhance platelet adhesion to endothelial cells under flow conditions: Distinct mechanisms of thrombogenic modulation. Thromb. Haemost. 83:338-344, 2000.
• D. Varon, R. Dardik, B. Shenkman, S. Kotev-Emeth, N. Farzame, I. Tamarin, N. Savion. A new method for quantitative analysis of whole blood platelet interaction with extracellular matrix under flow conditions. Thromb. Res. 85:283-294, 1997.     (DOI:10.1016/S0049-3848(97)00014-5)
• A. Battler, M. Scheinowitz, A. Bor, D. Hasdai, Z. Vered, E. Di Segni, N. Varda-Bloom, D. Nass, S. Engelberg, M. Eldar, M. Belkin, N. Savion. Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infarcted swine myocardium. J. Am. Coll. Cardiol. 22: 2001-2006, 1993.
• S. Pitaru, S. Kotev-Emeth, D. Noff, S. Kaffuler, N. Savion. Effect of basic fibroblast growth factor on the growth and differentiation of adult stromal bone marrow cells: enhanced development of mineralized bone-like tissue in culture. J. Bone Mineral Res. 8: 919-929, 1993.
• N. Savion, I. Vlodavsky, Z. Fuks. Interaction of T lymphocytes and macrophages with cultured vascular endothelial cells: Attachment, invasion and subsequent degradation of the subendothelial extracellular matrix. J. Cell. Physiol. 118: 169-178, 1984.  (DOI: 10.1002/jcp.1041180209)
• N. Savion, G.-M. Lui, R. Laherty, D. Gospodarowicz. Factors controlling proliferation and progesterone production by bovine granulosa cells in serum-free medium. Endocrinology 109: 409-420, 1981. http://dx.doi.org/10.1210/endo-109-2-409
• D. Gospodarowicz, G. Greenburg, J.-M. Foidart, N. Savion. The production and localization of laminin in cultured vascular and corneal endothelial cells. J. Cell. Physiol.  107: 171-183, 1981.  (DOI: 10.1002/jcp.1041070203)
• D. Gospodarowicz, I. Vlodavsky, N. Savion. The extracellular matrix and the control of proliferation of vascular endothelial and smooth muscle cells. J. Supramol. Struct. 13: 339-372, 1980.
• S. Eimerl, N. Savion, O. Heichal, Z. Selinger. Induction of enzyme secretion in rat pancreatic slices using the ionophore A-23187 and calcium: an experimental bypass of the hormone receptor pathway. J. Biol. Chem. 249: 3991-3993, 1974.