פרופ' מיכאל גורביץ

אמריטוס בביה"ס למדעי הצמח ואבטחת מזון
ביה"ס למדעי הצמח ואבטחת מזון אמריטוס
ניווט מהיר:
פרופ' מיכאל גורביץ
טלפון פנימי: 03-6409844
פקס: 03-6406100
משרד: בריטניה, 505

CV

A. EDUCATION

1967-1969     Hebrew University of Jerusalem,  Microbiology & Zoology      B.Sc.   1970

1970-1972     Hebrew University of Jerusalem,  Entomology                           M.Sc.  1973

1975-1980     Hebrew University of Jerusalem,  Biological Chemistry           Ph.D.  1980

Master's thesis: "Toxic effects of hemolymph of Tenebrionidae on other insects"

Under: Dr. E. Zlotkin

Doctoral dissertation: "Modulation of chloroplast membrane biosynthesis in Euglena"

Under: Prof. I. Ohad

 

B. FURTHER STUDIES

1981-1983     Washington Univ. Medical School, St. Louis, MO, USA, Dept.        Research

Microbiology & Immunology (RNA processing in prokaryotes)       Associate                                         

1984-1986     Michigan State Univ., East Lansing, MI, USA, Plant Research       Research

Laboratory (Interaction of nuclear and organelle genomes)            Associate

 

 

C. ACADEMIC AND PROFESSIONAL EXPERIENCE

C1. EMPLOYMENT

1972-1974     Hadassah Medical School, Jerusalem, Dept. of Molec. Biol.          Research

(Prof. N. Zitri: Production and purification of Penicilinase)              Assistant

1981-1983    Washington Univ. Medical School, St. Louis, MO, USA                  Research

Dept. Microbiology & Immunology (RNA processing)                     Associate

1984-1986     Michigan State Univ., East Lansing, MI, PRL                                 Research                        (Cyanobacterial and Rubisco molecular genetics)                          Associate

1987-1991     Tel-Aviv Univ., Faculty of Life Sciences, Dept. of Botany       Senior Lecturer

1. Cyanobacterial and Rubisco molecular biology

2. Genetic approach to the utilization of anti-insect selective

neurotoxins for the design of novel insecticides.

1992-1994     Tel-Aviv Univ., Faculty Life Sciences, Dept. Botany         Senior Researcher

1994-1999     TAU, Faculty Life Sciences, Dept. Plant Sciences          Associate Professor

1999-2015     Tel-Aviv Univ., Faculty Life Sciences, Dept. Plant Sciences           Professor

2015-              Tel-Aviv Univ., Faculty Life Sciences, Dept. Plant Sciences     Prof Emeritus

 

Main Area of Research: 

(1) Interaction of toxin ligands with voltage-gated sodium channels. Main objectives:

  (i) Unravel the surface of interaction of toxins with various sodium channel subtypes  (toxins bioactive surfaces and channel receptors);

    (ii) Identify molecular features underlying the varying preferences of toxin peptides for different insect and mammalian sodium channels;

   (iii) Design of channel-selective ligands that would serve as leads for development of novel insecticides and medical drugs;

   (iv) Study the activation and inactivation of these channels and how various toxins affect these activities.

(2) Regulation of inorganic carbon acquisition in cyanobacteria. Main objectives: 

(i) To better understand how Rubisco activity is regulated;

(ii) Develop a genetic system for manipulation and improvement of carbon acquisition;

(ii) Identify rate limiting factors of carbon acquisition in the Calvin cycle of   cyanobacteria.

 

 

C2. TEACHING EXPERIENCE

                                                                                                      Name of course Organizer

 

1971               Physiology of Insects                                                             Prof. E. Zlotkin

1972               Zoology: Vertebrates & Invertebrates                                  Dr. R. Lotan-Shiloh

                                                                                                                           & Prof. E. Zlotkin

1976               Introduction to Biochemistry                                                 Prof. A. Hochberg

1977               Introduction to Ecology                                                          Prof. M. Shiloh

                                                                                                                           & Prof. D. Zohari

1977               Dynamic Biochemistry                                                           Prof. N. de-Groot

1978               Biotechnology                                                                         Dr. S. Bauer

1979               Subcellular Organelles                                                          Prof. I. Ohad

1987-1989     Molecular Biology of Plants and Cyanobacteria                Dr. A. Breiman,

                                                                                                                           Dr. A. Zilberstein

                                                                                                                           Dr. M. Gurevitz

1987,1988     "New Horizons                                                                        Prof. B. Sneh

1991               "New Horizons"                                                                       Dr. S. Rosenblat

1994-1997     "New Horizons"                                                                       Prof. Z. Naor

2000-2003     "New Horizons"                                                                       Prof. Z. Naor

1994               Plant Physiology                                                                     Prof. S. Beer

1995               Introduction to Botany A                                                        Prof. Y. Waisel

1996               Venomous Animals (Eilat)                                                     Prof. M. Spira                                             (Hebrew University)

 

1998-2000     Light & colors in life of plants                                                (M. Gurevitz, B.                                                                                                     Epel, D. Chamovitz)

1998               Genetic engineering in biotechnology & medicine            Dr. Ithay Benhar

1998               Biotechnology in industry                                                      Prof. D. Gutnick

1991-2008     Molecular Biology of Photosynthetic Prokaryotes             Dr. M. Gurevitz

2002-2014     Plant Physiology                                                                     Prof. M. Gurevitz

2002-2008     Plant Physiology Laboratory                                                 Prof. M. Gurevitz

 

 

D. ACTIVE PARTICIPATION IN SCIENTIFIC MEETINGS

1975  Annu. Meet. Israel Soc. Biochem., Beer-Sheva, Israel.

1976  Annu. Meet. Israel Soc. Biochem., Rehovot, Israel.

1978  "Photosynthesis 78", Spetsai, Greece.

1981  "RNA Processing", Cold Spring Harbor, USA.

1982  "RNA Processing", Cold Spring Harbor, USA.

1983  "RNA Processing", Cold Spring Harbor, USA.

1983  "Stadler Genetic Symposium", St. Louis, Missouri, USA.

1984  "Cyanobacterial Ecology, Physiology and Molecular

           Genetics", Turkey-Run, Indiana, USA.                                                          Invited speaker.

1985  "1st Internatl. Cong. Plant Molecular Biology", Savannah, Georgia, USA.     Invited speaker.

1986  "7th Internatl. Cong. Photosynthesis", Brown, Rhode Island, USA.

1989  "Photosynthetic Prokaryotes", Amsterdam, Holland.

1991  "Photosynthetic Prokaryotes", Amherst, MA, USA.

1991  "Frontiers of Biotech. in Agriculture" Internat. Conf., Sea of Galilee, Israel.  Invited speaker.

1993  1st Natl. Cong. Peptides & Drugs Release. Jerusalem, Israel.

1993  Plant Biotechnology Internatl. Workshop. TAU, Israel.         Invited speaker & co-Organizer.

1993  XI European Meeting IST. Arezzo, Italy.

1994  10th World Cong. on Animal, Plant  &  Microbial Toxins, Tel-Aviv, Israel.

                                                                                                           Invited speaker & Chairperson.

1994   Modern Agriculture & the Environment Internatl. Conf., Rehovot, Israel.      Invited speaker

1995   Natural Compounds of Biol. Activity in Med. & Agriculture, Tel-Aviv, Israel. Invited speaker

1995   FISEB, Federation Israeli Societies of Exper. Biology. Eilat, Israel.              Invited speaker

1996   Korea-Israel Biotechnological Workshop. Jerusalem, Israel.                        Invited speaker

1997   5th Internatl. Cong. Invertebrate Neurochem. & neurophysiol. Eilat, Israel.   Invited speaker

1997   12th World Cong. Animal, Plant & Microb. Toxins. Cuernavaca, Mexico.

                                                                                                           Invited speaker & Chairperson 

1998   NEUROTOX 98: Progress in Neuropharmacology and Neurotoxicology

of Pesticides and Drugs. Oxford, UK.                                                           Invited speaker

1998   FISEB, Federation of Israeli Soc. of Exp. Biology. Eilat, Israel.                    Invited speaker

2000  13th World Cong. Animal, Plant & Microbial Toxins. Paris, France.                Invited speaker

2001  Internatl. Congress on Neuroethology, Bonn, Germany.                               Invited speaker

2003  14th World Cong. Animal, Plant & Microbial Toxins. Adelaide, Australia.       Invited speaker

2005   FISEB, Federation of Israeli Societies Experimental Biology. Eilat, Israel.   Invited speaker  

2006  15th World Cong. Animal, Plant & Microbial Toxins. Glasgow, Scotland.       Invited speaker

2008  PepCon-2008, World Congress proteins and peptides, Shen-Chen, China, Invited speaker

2008   European Cong. Animal, Plant & Microbial Toxins, Leuven, Belgium,          Invited speaker

2010   European Cong. Animal, Plant & Microbial Toxins, Valencia, Spain             Invited speaker

2013  World Cong. Animal, Plant & Microbial Toxins. Honolulu, Hawai                   Invited speaker

2013  Asian Cong. Animal, Plant & Microbial Toxins, Vladivostok, Russia             Invited speaker

 

E. ACADEMIC AND PROFESSIONAL RESPONSIBILITIES AND GRANTS

E1.1.  BARD panel member in the Biotechnology section (1992, 1994).

2.  co-Organizer with Prof. I. Barash the "Plant Biotechnology" Internatl. Conf.

          at Tel-Aviv University on May 17, 1993.

     3.  Panel member of Chief Scientist of Agriculture, Biotechnology section (1994).

     4.  Panel member, section of Plant Sciences, Israel Academy Science (1995, 2000).

     5.  Member in University Committee for graduate students (1997-2004, 2006-2012).

     6.  Member in Faculty Committee for Postdoc fellowships (1997-2008).

     7.  Member in the Faculty Committee for Academic planning (1998-2000).

     8.  Chairman of the Faculty Committee for Safety (1999, 2000).

     9.  Member of Institute Steering Committee of Structural Biology (1998-2008).

10.  BARD panel member in the Biotechnology section (1999, 2000).

11. Panel member of Chief Scientist of Agriculture, Biotechnology section (1999,2000).

12. Head of University Safety Committee (2001-2008).

 

 

E2. GRANTS RECEIVED AT TEL AVIV UNIVERSITY

 

   Topic                                                               Grantor               Duration              Total

  1. Genetic modification of Rubisco                   BSF (PI)            1987-1989         $ 71000

 

  2. Genetic modification of Rubisco                   NCRD (PI)         1987-1990         $ 65000

 

  3. Regulation of psbA gene expression            Wolf  (PI)           1987-1989         $ 20000

 in cyanobacteria                                       (Israel Academy)

 

  4. Genetic engineering of Rubisco                   Hertz (PI)             1987                 $ 2000

 

  5. The regulatory mechanism of the                TAU (PI)               1987                 $ 8000

  expression of psbA in cyanobacteria

 

  6. Nitrogen regulation system in                      BSF (co-PI)        1989-1991        $ 105000

  cyanobacteria

 

  7. Nitrogen regulation system in                      Israel (co-PI)      1988-1991          $ 71000

  cyanobacteria                                              Academy

 

  8. Utilization of insect selective neuro-            Conservation,     1990-1991          $ 25000

  toxins from scorpions for future design       Food & Health

  of insecticides                                             Foundation  (PI)

 

  9. Structure-function relationships of insect-     TAU (PI)            1991-1992          $ 6500

 selective neurotoxins derived from

     scorpion venoms: A genetic approach

 

10. Insect specific a-neurotoxins from               BARD (PI)           1992-1995      $ 250000

scorpion venoms: Mode of action &

structure-function relationships

 

11. Expression of scorpion neurotoxins               French- (CI)        1993-1994      $ 120000

in eukaryotic systems: Applicability               Israel

      and structure function relationships

 

12. Dually functional recombinant baculo-          BARD (CI)           7.93-6.96       $ 270000

virus expressing, both, the excitatory                                                         

and depressant insect selective toxins

 

13. Functional & molecular characterization        Israel (co-PI)      1993-1996      $ 100000

of an animal-like HCO3- transporter in            Academy                                 

marine macroalgae and cyanobacteria

 

14. Construction of transgenic tobacco with        Israel (co-PI)       1995-1998      $ 30000

scorpion anti-insect selective toxins              Agricultural Ministry                                

                                                                   

15. Structural elements dictating insecticidal       BARD (PI)          1995-1998      $ 300000

 properties of scorpion alpha neurotoxins

 

16. Cyanobacterial host suitable for                     RITE (PI)           1996-1997       $ 70000

selection of modified Rubisco                         Japan

 

17. Selection of Rubisco mutants using an           BSF   (PI)           9.96-8.99       $105000

rbc and ccm negative cyanobacterial host

 

18. Depressant and excitatory scorpion toxins:    Israel                 1997-2000       $130000

structure-function & specificity to insects        Academy         

 

19. Improvement of insecticidal efficacy of           DIARP              1997-1999         $ 30000

baculoviruses with scorpion insecticidal        (Israel-Holland)

toxins and structure-function relationships

 

20. Interacting domains of anti-insect scorpion      BARD (PI)         1998-2001    $ 285000

toxins and their sodium channel binding

      sites: Structure, cooperative interactions

      with agrochemicals, and application

 

21. A functional genomics and high throughput    Tashtiot (co-PI)    1999-2000   $ 40000

      selection approach for detection of novel        Israel Ministry

      bioactive peptides                                            of Science

 

22. Molecular dissection of a voltage-gated           Israel (CI)          2000-2004    $ 230000

      sodium channel receptor site that binds           Academy

      exclusively anti-insect specific neurotoxins

                                                                                  

23. Determination of the architectural features       BARD (co-PI)    2001-2004   $ 300000

      of sodium channel receptors that bind anti-        (With D. Gordon)

      insect selective toxins for design of

      environmentally safe pesticides

 

24. Molecular dissection of a sodium channel            Israel (CI)     2000-2004    $ 230000

      receptor site that binds exclusively anti-insect      Academy

      specific neurotoxins

 

25. The bioactive site of scorpion toxins capable         Israel (PI)  2001-2004   $ 150000

      of differentiating between sodium channel             Academy

      subtypes as a model for future design of

      drugs and insecticides

 

26. Molecular basis of Ribulose bisphosphate           Israel  (CI)     2002-2006   $ 160000

      carboxylase/oxygenase (Rubisco) regulation       Academy

      by redox

 

27. Bioactive sites of scorpion toxins capable of        Israel  (PI)     2002-2006   $ 240000        

      differentiating between sodium channel               Academy

      subtypes as models for future design of

      selective drugs and insecticides

 

28. Interaction of scorpion beta-toxins with                   GIF (CI)       2002-2005   $ 200000

      mammalian and insect sodium channels:

      Structural features the determine the unique

      effects on channel activation and the selectivity

      for channel subtypes

 

29. Limitations of cyanobacterial photosynthesis:         GIF (CI)       2002-2005   $ 170000  

      Does the carboxylation enzyme Rubisco indeed

      limit the rate of photosynthesis

 

30. Regulation of ribulose bisphosphate carboxylase   Israel (CI)    2002-2006   $ 122000

      /oxygenase by inorganic phosphate                          Academy                        

 

31. Sensitivity of a wide array of insect sodium             BARD  (PI)  2003-2007   $ 300000

      channels to anti-insect selective toxins; key

      for preventing resistance buildup to pyrethroids

 

32. Subtle modifications in the bioactive surface           Israel (CI)   2003-2007    $ 240000

      of scorpion toxins confer major differences in         Academy

      specificity for sodium channel subtypes:

      Design of target selective ligands

 

33. CONCO: Applied venomics of the cone                    EU  (PI)      2007-2012    $ 300000

      snail species Conus consors

 

34.  Learning from Nature how to design                        BARD (CI)  2007-2010    $ 270000

       anti-insect selective pesticides - Clarification

       of the interacting face between insecticidal

       toxins and their Na-channel receptors

 

35.  Receptor sites and antagonists for paralytic           NIH (PI)      2007-2012    $ 560000

  neurotoxins

 

36.  The unexpected specificity of a sea anemone       BARD (CI)  2007-2010    $ 270000

  small toxin for insect Na-channels and its synergic

  effects with various insecticidal ligands: A new

  model to mimic

 

37.  Molecular basis of the difference in effects on       Israel (PI)    2008-2012    $ 200000

  activation and in selectivity among neurotoxins    Academy

  that bind to the same macrosite at voltage-gated

  Na-channels

 

38.  The rate limiting steps of cyanobacterial                 Israel (CI)    2008-2012   $ 160000  

       photosynthesis                                                             Academy

 

39.  Development of novel herbicides                              ADAMA     2010-2012      $500000

 

                                

 

F. MEMBERSHIP IN PROFESSIONAL SOCIETIES

Israel Tissue Culture and Plant Molecular Biology Society

International Society Plant Molecular Biology

International Society of Toxinology

 

 

G. STUDENTS SUPERVISED

Total number of graduated MSc students:                                                                      23

Total number of graduated PhD students:                                                                      15

Number of students that continued on to PhD after

completing MSc in the lab:                                                                                            8

Number of Post Docs:                                                                                                          7

 

G1. DOCTORAL STUDENTS

                                                                                                    Present tenure track Position

1989-1993        Doron Amichay                                            Lecturer, Ben Gurion Univ.

1989-1994        Rachel Cohen-Kupiec  (co-supervisor)   Senior Researcher

1991-1996        Noam Zilberberg                                         Assoc. Prof., Ben Gurion Univ.

1994-1998        Eduard Gershburg   (co-supervisor)        Assoc. Prof., Canada

1994-1999        Zinger Alon  (co-supervisor)                      Senior Researcher

1995-2000        Oren Froy                                                      Professor, HUJI Rehovot

1997-2001        Regev Avital   (co-supervisor)                   Senior Researcher Weizmann

2001-2006       Karbat Izhar                                                  Senior Researcher, Weizmann

2003-2008       Cohen Lior                                                    Senior Lecturer, Haifa University

2004-2009        Kahn Roy                                                      Senior Researcher

2004-2009        Moran Yehu                                                  Assoc. Prof., HUJI Jerusalem

2005-2011        Gur Maya

2005-2009        Paldi Tzur

2007-2010        Gulik Alina

2011-2016        Altman Gueta Hagit

 

G2. M.Sc. STUDENTS

1987-1988        Yael Keren

1988-1990        Hana Rosenfeld (Edrei) (co-supervisor)

1989-1990        Noam Zilberberg

1990-1992        Daniel Urbach

1992-1994        Sharon Rashi

1994-1995        Oren Froy

1995-1997        David Strugatzky

1998-2001        Rakefet Golan (Spielberg)

1998-2000        Hagit Altman (Gueta)

1999-2001        Ruthie Wilunsky

1999-2000        Izhar Karbat

2000-2001        Jonathan Boxman

2002-2003        Lior Cohen

2003-2005        Roy Kahn

2003-2005        Yehu Moran

2003-2005        Anat Idan

2003-2005        Maya Gur

2004-2006       Alina Gulik (co-supervisor)

2004-2006       Wolff Yael

2005-2007       Mor Gil

2007-2008       Weinberger Hagar

2007-               Meller Hadas

2007-2009       Hanuna Assaf                       

 

G3. POSTDOCS

 

1988-1991        Dr. Meir Sheffer

1990-1991        Dr. Ruth Levitz

1994-present   Dr. Michael Turkov

1997-present   Dr. Yehouda Marcus

1999-present   Dr. Dalia Gordon

2003-2005        Dr. Jacob Van Dam

2008-2009       Dr. Tali Lavi

 

Research Interests

Main Area of Research: 

 

(1) Interaction of toxin ligands with voltage-gated sodium channels. Main objectives:

  (i) Unravel the surface of interaction of these ligands with various channel subtypes (toxins bioactive surfaces and channel receptors);

   (ii) Identify molecular features underlying the varying preferences of ligands for different insect and mammalian channels;

   (iii) Design channel-selective ligands that would serve as leads for novel insecticides and medical drugs;

   (iv) Study the activation and inactivation of these channels and how various toxins affect these activities.

(2) Regulation of inorganic carbon aquisition in cyanobacteria. Main objectives: 

(i) To better undestand how Rubisco activity is regulated;

(ii) To develop a genetic system for manipulation and improvement of carbon aquisition;

(ii) To identify the rate limiting factors of carbon aquisition in the Calvin cycle of cyanobacteria.

Publications

  1. Zlotkin, E., Gurevitz, M. and Shulov, A. (1972) Toxic effects of tenebrionid beetles hemolymph on insects. Toxicon, 10: 537-542.
  2. Zlotkin, E., Gurevitz, M. and Shulov, A. (1972) Toxic effects of tenebrionid beetles' hemolymph on insects. In Animal and Plant Toxins (E. Keiser, ed.), pp. 135-142, W. Goldmann Verlag.
  3. Zlotkin, E., Gurevitz, M. and Shulov, A. (1973) The toxic effects of phenoloxidase from the hemolymph of tenebrionid beetles. J. Insect Physiol., 19:1057-1065.
  4. Gurevitz, M., Kratz, H. and Ohad, I. (1975) Chloroplastic origin of membrane proteins required for photosystem II activity in Euglena chloroplasts. Isr. J. Med. Sci. 11:1191-1192.
  5. Gurevitz, M., Kratz, H. and Ohad, I. (1977) Polypeptides of chloroplastic and cytoplastic origin required for development of photosystem II activity, and chlorophyll-protein complexes in Euglena gracilis Z chloroplast membranes. Biochim. Biophys. Acta, 461:475-488.
  6. Ohad, I., Bar-Nun, S., Cahen, D., Gershoni, J., Gurevitz, M., Kretzer, F., Shantz, R. and Sochat, S. (1977) Biogenesis of chloroplast membranes in algae. In Research in Photobiology, (A. Castellani, ed.) pp. 531-537, Springer, Boston MA.
  7. Cahen, D., Malkin, S., Gurevitz, M. and Ohad, I. (1978) Development of photosystem II apparatus in chloroplasts of Euglena gracilis Z during light-dark-light cycles. Plant Physiol., 62:1-5.
  8. Ohad, I., Bar-Nun, S., Cahen, D., Gershoni, J., Gurevitz, M., Lavintman, N. (1978) Stepwise synthesis and assembly of photosynthetic membranes in algae. In Photosynthesis 77, Proc. 4th Intern. Cong. Photosynthesis (D.O. Hall, J. Coombs and T.W. Goodwin, eds.), pp. 517-527, The Biochemical Society, London.
  9. Gurevitz, M., Watson, N. and Apirion, D. (1982) A cleavage site of ribonuclease F: A putative processing endoribonuclease from Escherichia coli. Eur. J. Biochem., 124:553-559.
  10. Jain, S., Gurevitz, M. and Apirion, D. (1982) A small RNA that complements mutants in the RNA processing enzyme Ribonuclease P. J. Mol. Biol., 162:515-533.
  11. Gurevitz, M., Jain, S. and Apirion, D. (1983) Identification of a precursor molecule for the RNA moiety of the processing enzyme Ribonuclease P. Proc. Natl. Acad. Sci. USA, 80:4450-4454.
  12. Gurevitz, M. and Apirion, D. (1983) Interplay among processing and degradative enzymes and precursor RNA molecules in the selective maturation and maintenance of RNA molecules. Biochemistry, 22:4000-4005.
  13. Gurevitz, M. and Apirion, D. (1983) Processing of bacteriophage T4 tRNAs: A precursor of species 1 RNA. FEBS Lett., 159:180-184.
  14. Watson, N., Gurevitz, M., Ford, J. and Apirion, D. (1984) Self cleavage of a precursor RNA from bacteriophage T4. J. Mol. Biol., 172:301-323.
  15. Gurevitz, M. and Apirion, D. (1985) The ribonuclease III-processing site near the 5' end of an RNA precursor of bacteriophage T4 and its effect on termination. Eur. J. Biochem., 147:581-586.
  16. Apirion, D., Dallmann, G., Gurevitz M., Miczak, A., Pragai, B., Subbarao, M.N., Szeberenyi, T. and Watson, N. (1985) Endonucleolytic Processing of RNA in a Prokaryotic Cell. In UCLA Symposia on Molecular and Cellular Biology New Series, Vol. 26, Nuclear Envelope Structure and RNA Maturation (Smuckler, E. A. and G. A. Clawson, eds.), pp. 331-354, A. R. Liss, Inc. New York, N.Y.
  17. Apirion, D., Dallmann, G., Gurevitz, M., Miczak, A., Szeberenyi, J., Tomcsanyi, T., Subbarao, M.N. and Watson, N. (1988) Specificity in RNA Processing Reactions in Escherichia Coli. In UCLA Symposia on Molecular and Cellular Biology New Series, Vol. 26, Nuclear Envelope Structure and RNA Maturation (Smuckler, E. A. and G. A. Clawson, eds.), pp. 331-354, A.R. Liss, Inc. New York, N.Y.
  18. McIntosh, L., Williams, J.G.K., Somerville, C.R. and Gurevitz, M. (1985) Genetic modification of photosynthesis. In Molecular form and function of the plant genome (van Vloten-Doting, L. G., S. P. Groot, T. C. Hall, eds.), pp. 335-346, Plenum Press.
  19. Somerville, C. R., McIntosh, L., Fitchen, J. and Gurevitz, M. (1985) The cloning and expression in E. coli of RuBP carboxylase/oxygenase large subunit genes. Methods in Enzymol., 118:419-433.
  20. Gurevitz, M., Somerville, C. R. and McIntosh, L. (1985) Pathway of assembly of ribulose bisphosphate carboxylase/oxygenase from Anabaena 7120 expressed in Escherichia coli. Proc. Natl. Acad. Sci. USA, 82:6546-6550.
  21. Jansson, C., Debus, R. J., Osiewacz, H. D., Gurevitz, M. and McIntosh, L. (1987) Construction of an obligate photoheterotrophic mutant of the cyanobacterium Synechocystis 6803. Plant Physiol., 85:1021-1025.
  22. Jansson, C., Debus, R. J., Osiewacz, H. D., Gurevitz, M. and McIntosh, L. (1987) Genetic modification of psbA genes in the cyanobacterium Synechocystis 6803. In Plant Gene Systems and their Biology (J. L. Key and L. McIntosh, eds.), Vol. 62, pp. 371-381, New York, A. R. Liss Inc.
  23. Gurevitz, M., Zlotkin, E. and Zilberberg, N. (1990) Characterization of the transcript for a depressant insect selective neurotoxin gene with an isolated cDNA clone from the scorpion Buthotus judaicus. FEBS Lett., 269:229-232.
  24. Zilberberg, N., Zlotkin, E. and Gurevitz, M. (1991) The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon, 29:1155-1158.
  25. Gurevitz, M., Osiewacz, H. D. and Keren, Y. (1991) Molecular evidence for interchromosomal recombination in the cyanobacterium Synechocystis sp. PCC6803. Plant Sci., 78:217-224.
  26. Cohen, Y. and Gurevitz, M. (1991) Ecology, Physiology and Molecular Genetics of Cyanobacteria. In The Prokaryotes (A. Balows, H. G. Trueper, M. Dworkin, W. Harder, and K. H. Schleifer, eds.), Vol. II, Chapter 98, pp. 2079-2104, Springer-Verlag, Second Edition.
  27. Gurevitz, M., Urbach, D., Zlotkin, E. and Zilberberg, N. (1991) Nucleotide sequence and structure analysis of a cDNA encoding an alpha insect toxin from the scorpion Leiurus quinquestriatus hebraeus. Toxicon, 29:1270-1272.
  28. Zilberberg, N., Zlotkin, E. and Gurevitz, M. (1992) Molecular analysis of cDNA and transcript encoding the depressant insect neurotoxin of the scorpion Leiurus quinquestriatus hebraeus. Insect Biochem. Molec. Biol., 22:199-203.
  29. Amichay, D., Sheffer, M. and Gurevitz, M. (1992) Restoration of the wild-type locus in an RuBP Carboxylase/Oxygenase mutant of Synechocystis PCC6803 via targeted gene recombination. Molec. Gen. Genet., 235:247-252.
  30. Zlotkin, E., Gurevitz, M., Fowler, E., Moyer, M. and Adams, M. E. (1993) Depressant insect selective neurotoxins from scorpion venom: chemistry, action and gene cloning. Arch. Insect Biochem. Physiol., 22:55-73.
  31. Amichay, D., Levitz, R. and Gurevitz, M. (1993) Construction of a Synechocystis PCC6803 mutant suitable for the study of a variant hexadecameric RuBP Carboxylase/Oxygenase enzymes. Plant Mol. Biol., 23:465-476.
  32. Zilberberg, N. and Gurevitz, M. (1993) Rapid isolation of full-length cDNA clones by "inverse PCR": Purification of a scorpion cDNA family encoding a-neurotoxins. Anal. Biochem., 209:203-205.
  33. Cohen-Kupiec, R., Gurevitz, M., and Zilberstein, A. (1993) Expression of glnA in the cyanobacterium Synechococcus strain PCC7942 is initiated from a single nif-like promoter, under various nitrogen conditions. J. Bacteriol., 175:7727-7731.
  34. Ogawa, T., Amichay, D. and Gurevitz, M. (1994) Isolation and characterization of the ccmM gene required by the cyanobacterium Synechocystis PCC6803 for inorganic carbon utilization. Photosynth. Res., 39:183-190.
  35. Gurevitz, M. and Zilberberg, N. (1994) Advances in molecular genetics of scorpion neurotoxins. J. Toxicol. Toxin Rev., 13:65-100.
  36. Zlotkin, E., Eitan, M., Pelhate, M., Chejanovsky, N., Gurevitz, M. and Gordon, D. (1994) Insect specific neurotoxins from scorpion venom that affect sodium current inactivation. J. Toxicol. Toxin Rev., 13:25-43.
  37. Cohen-Kupiec, R., Zilberstein, A. and Gurevitz, M. (1995) Characterization of cis elements that regulate the expression of glnA in Synechococcus sp. strain PCC7942. J. Bacteriol., 177:2222-2226.
  38. Gurevitz, M., Zilberberg, N., Urbach, D., Gordon, D., Zlotkin, E. and Chejanovsky, N. (1995) Alpha scorpion neurotoxins and baculoviruses: A working model for the design of Novel selective insecticides. Bielefeld, Germany, In Bielefelder Okologische Beitrage, 8:25-41.
  39. Chejanovsky, N., Zilberberg, N., Rivkin, H., Zlotkin, E. and Gurevitz, M. (1995) Functional expression in insect cells and in lepidopterous larvae of a scorpion anti-insect alpha neurotoxin. FEBS Lett., 376:181-184.
  40. Zilberberg, N., Gordon, D., Zlotkin, E., Pelhate, M. Adams, M.E., Norris, T. and Gurevitz, M. (1996) Functional expression and genetic modification of an alpha scorpion neurotoxin. Biochemistry, 35:10215-10222.
  41. Gurevitz, M., Zilberberg, N., Froy, O., Urbach, D., Zlotkin, E., Hammock, B. D., Herrmann, R., Moskowitz, H. and Chejanovsky, N. (1996) Utilisation of scorpion insecticidal neurotoxins and baculoviruses for the design of novel selective biopesticides. In Modern Agriculture and the Environment (D. Rosen and E. Tel-Or, eds.), pp. 81-96, KluwerAcademic Publ.
  42. Zilberberg, N., Froy, O., Cestele, S., Loret, E., Arad, D., Gordon, D. and Gurevitz, M. (1997) Identification of structural elements of a scorpion alpha neurotoxin important for receptor-site recognition. J. Biol. Chem., 272:14810-14816.
  43. Tugarinov, V., Kustanovitz, I., Zilberberg, N., Gurevitz, M. and Anglister, Y. (1997) Solution structures of a highly insecticidal recombinant scorpion a-toxin and a mutant with increased activity. Biochemistry, 36:2414-2424.
  44. Turkov, M., Rashi, S., Zilberberg, N., Gordon, D., BenKhalifa, R., Stankiewicz, M., Pelhate, M. and Gurevitz, M. (1997) Expression in Escherichia coli and reconstitution of a functional recombinant depressant scorpion neurotoxin specific against insects. Prot. Exp. Purific., 10:123-131.
  45. Benkhalifa, R., Stankiewicz, M., Lapied, B., Turkov, M., Zilberberg, N., Gurevitz, M. and Pelhate, M. (1997) Refined electrophysiological analysis suggests that scorpion depressant neurotoxins are sodium channel openers rather than blockers. Life Sci., 61:819-830.
  46. Gershburg, E., Stockholm, D., Froy, O., Rashi, S., Gurevitz, M. and Chejanovsky, N. (1998) Baculovirus-mediated expression of a scorpion depressant toxin improves significantly the insecticidal efficacy achieved with excitatory toxins. FEBS Lett., 422:132-136.
  47. Gurevitz, M., Froy, O., Zilberberg, N., Turkov, M., Strugatsky, D., Gershburg, E., Lee, D., Adams, M. E., Tugarinov, V., Anglister, J., Shaanan, B., Loret, E., Stankiewicz, M., Pelhate, M., Gordon, D. and Chejanovsky, N. (1998) Sodium channel modifiers from Scorpion venom: Structure-activity relationship, mode of action, and application. Toxicon, 6:1671-1682.
  48. Gordon, D., Savarin, P., Gurevitz, M. and Zinn-Justin, S. (1998) Functional anatomy of scorpion toxins affecting sodium channels. J. Toxicol. Toxin Rev., 17:131-158.
  49. Oren, D., Froy, O., Amit, E., Kleinberger-Doron, N., Gurevitz, M. and Shaanan, B. (1998) An excitatory scorpion toxin with a distinctive feature: an additional a-helix at the C-terminus and its implications for interaction with insect sodium channels. Structure, 6:1095-1103.
  50. Froy, O. and Gurevitz, M. (1998) Membrane potential modulators: a thread of scarlet from plants to humans. FASEB J., 12:1793-1796.
  51. Froy, O., Sagiv, T., Poreh, M., Urbach, D., Zilberberg, N. and Gurevitz, M. (1999) Dynamic diversification from a putative common progenitor of scorpion toxins affecting sodium, potassium and chloride channels. J. Mol. Evol., 48:187-196.
  52. Gurevitz, M., Froy, O., Zilberberg, N., Shaanan, B., Adams, M. E., Anglister, J., Pelhate, M., Chejanovsky, N. and Gordon, D. (1999) Elucidation of the active site and potential applications of sodium channel modifiers from scorpion venom. In Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs (D. J. Beadle, ed.), pp. 67-80, Oxford, UK.
  53. Froy, O., Zilberberg, N., Gordon, D., Turkov, M., Gilles, N., Stankiewicz, M., Pelhate, M., Loret, E., Oren, D., Shaanan, B. and Gurevitz, M. (1999) The putative bioactive surface of insect-selective scorpion excitatory neurotoxins. J. Biol. Chem., 274:5769-5776.
  54. Froy, O., Zilberberg, N., Chejanovsky, N., Anglister, J., Loret, E., Shaanan, B., Gordon, D. and Gurevitz, M. (2000) Scorpion neurotoxins: Structure/function relationships and application in agriculture. Pest. Manag. Sci., 56:472-474.
  55. Lee, D., Gurevitz, M. and Adams, M. E. (2000) Modification of synaptic transmission and sodium channel inactivation by the insect-selective scorpion toxin LqhaIT. J. Neurophysiol., 83:1181-1187.
  56. Marcus, Y. and Gurevitz, M. (2000) Activation of cyanobacterial RuBP-carboxylase/ oxygenase is facilitated by inorganic phosphate via two distinct mechanisms. Eur. J. Biochem., 267:5995-6003.
  57. Gilles, N., Krimm, I., Bouet, F., Froy, O., Gurevitz, M., Lancelin, J-M. and Gordon, D. (2000) Structural implications on the interaction of scorpion a-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding. J. Neurochem., 75:1735-1745.
  58. Gurevitz, M., Gordon, D., Ben-Natan, S., Turkov, M. and Froy, O. (2001) Diversification of neurotoxins by C-tail ‘wiggling’ - a scorpion recipe for survival. FASEB J., 15:1201-1205.
  59. Gilles, N., Harrison, G., Karbat, I., Gurevitz, M., Nicholson, G. M. and Gordon, D. (2002) Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider d-Atracotoxin. Eur. J. Biochem., 269:1500-1510.
  60. Gordon, D., Gilles, N., Bertrand, D., Molgo, J., Nicholson, G. N., Sauviat, M. P., Shichor, I., Lotan, I., Gurevitz, M., Kallen, R. G. and Heinemann, S. H. (2002) Scorpion toxins differentiating among neuronal sodium channel subtypes: Nature’s guide for design of selective drugs. In Perspectives in Molecular Toxinology (Menez, A., ed.), pp. 215-238, Wiley and Sons, Chichester, UK.
  61. Gurevitz, M., Zilberberg, N., Froy, O., Turkov, M., Vilunsky, R., Karbat, I., Anglister, J., Shaanan, B., Pelhate, M., Adams, M. E., Gilles, N., and Gordon, D. (2002) Diversification of toxic sites on a conserved protein scaffold: a scorpion recipe for survival. In Perspectives in Molecular Toxinology (Menez, A., ed.), pp. 239-253, Wiley and Sons, Chichester, UK.
  62. Gordon, D. and Gurevitz, M. (2003) The selectivity of scorpion a-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface. Toxicon, 41:125-128.
  63. Marcus, Y., Altman-Gueta, H., Finkler, A. and Gurevitz, M. (2003) The dual role of cysteine172 in redox regulation of Rubisco activity and degradation. J. Bacteriol., 185:1509-1517.
  64. Regev, A., Rivkin, H., Inceoglu, B., Gershburg, E., Hammock, B. D., Gurevitz, M. and Chejanovsky, N. (2003) Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively. FEBS Lett., 537:106-110.
  65. Gilles, N., Gurevitz, M. and Gordon, D. (2003) Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control. FEBS Lett., 540:81-85.
  66. Gordom, D. and Gurevitz, M. (2003) The selectivity of scorpion alpha-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface. Toxicon, 41: 125-128.
  67. Gordon, D., Zilberberg, N., Ilan, N., Gilles, N., Urbach, D., Cohen, L., Karbat, I., Froy, O., Gaathon, A., Kallen, R. G., Benveniste, M. and Gurevitz, M. (2003) An ‘Old World’ scorpion b-toxin that recognizes both insect and mammalian sodium channels: a possible link towards diversification of b-toxins. Eur. J. Biochem., 270:2663-2670.
  68. Froy, O. and Gurevitz, M. (2003) New insight on scorpion divergence inferred from comparative analysis of toxin structure, pharmacology and distribution. Toxicon, 42:549-555.
  69. Froy, O. and Gurevitz, M. (2003) Arthropod and Mollusk defensins - evolution by exon shuffling. Trends Genet., 19:684-687.
  70. Cohen, L., Karbat, I., Gilles, N., Froy, O., Corzo, G., Angelovici, R., Gordon, D. and Gurevitz, M. (2004) Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative ‘hot spot’ common to all scorpion b-toxins affecting Na+ channels. J. Biol. Chem., 279:8206-8211.
  71. Karbat, I., Cohen, L., Gilles, N., Gordon, D. and Gurevitz, M. (2004) Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels. FASEB J., 18:683-689.
  72. Froy, O. and Gurevitz, M. (2004) Arthropod defensins illuminate the divergence of scorpion neurotoxins. J. Pept. Sci., 10:714-718.
  73. Karbat, I., Frolow, F., Froy, O., Gilles, N., Cohen, L., Turkov, M., Gordon, D. and Gurevitz, M. (2004) Molecular basis of the high insecticidal potency of scorpion a-toxins. J. Biol. Chem., 279:31679-31686.
  74. Tan, J., Liu, Z., Wang, R., Huang, Z., Chen, A. C., Gurevitz, M. and Dong, K. (2005) Identification of amino acid residues critical for pyrethroid binding to insect sodium channels. Mol. Pharmacol., 67:513-522.
  75. Corzo, G., Escoubas, E., Villegas, E., Karbat, I., Gordon, D., Gurevitz, M., Nakajima, T. and Gilles, N. (2005) A spider toxin that induces a typical effect of scorpion a-toxins but competes with b-toxins on binding to insect sodium channels. Biochemistry, 44:1542-1549.
  76. Cohen, L., Karbat, I., Gilles, N., Ilan, N., Gordon, D. and Gurevitz, M. (2005) Common features in the functional surface of scorpion b-toxins and elements that confer specificity for insect and mammalian voltage-gated Na-channels. J. Biol. Chem., 280:5045-5053.
  77. Marcus, Y., Altman-Gueta, H., Finkler, A. and Gurevitz, M. (2005) Mutagenesis at two distinct phosphate-binding sites unravels their differential role in regulation of Rubisco activation and catalysis. J. Bacteriol., 187:4222-4228.
  78. Strugatsky, D., Zilberberg, N., Ilan, N., Turkov, M., Cohen, L., Stankiewicz, M., Pelhate, M., Gilles, N., Gordon, D. and Gurevitz, M. (2005) Expression of a gene family encoding a novel scorpion depressant toxin illuminates the key role of asparagine-58 in activity on insect neuronal sodium channels. Biochemistry, 44:9179-9187.
  79. Cohen, L., Gilles, N., Karbat, I., Ilan, N., Gordon, D. and Gurevitz, M. (2006) Direct evidence that receptor site-4 of sodium channel gating modifiers is not dipped in the phospholipid bilayer of neuronal membranes. J. Biol. Chem., 281:20673-20679.
  80. Moran, Y., Cohen, L., Kahn, R., Karbat, I., Gordon, D. and Gurevitz, M. (2006) Expression and mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on insect voltage-gated sodium channels. Biochemistry, 45:8864-8873.
  81. Moran, Y. and Gurevitz, M. (2006) When positive selection of neurotoxin genes is missing - the riddle of the sea anemone Nematostella vectensis. FEBS J., 276:3886-3892.
  82. Cohen Y and Gurevitz M (2006) The Cyanobacteria - Ecology, Physiology and Molecular Genetics. In The Prokaryotes, Chapter 2.2, 4:1074-1098.
  83. Regev, A., Rivkin, H., Gurevitz, M. and Chejanovsky, N. (2006) New measures of insecticidal efficacy and safety obtained with the 39K promoter of a recombinant baculovirus. FEBS Lett., 580:6777-6782.
  84. Snir, A., Gurevitz, M. and Marcus, Y. (2006) Photosynthetic diurnal rhythm in aerial leaves of the amphibious-plant Nuphar lutea is induced by alterations in Rubisco activity and stomatal behavior. Photosynthesis Res., 90:233-242.
  85. Karbat, I., Turkov, M., Cohen, L., Kahn, R., Gordon, D., Gurevitz, M. and Frolow, F. (2007) X-ray structure and mutagenesis of the scorpion depressant toxin LqhIT2 reveals key determinants crucial for activity and anti-insect selectivity. J. Mol. Biol.­, 366:586-601.
  86. Gurevitz, M., Karbat, I., Cohen, L., Ilan, N., Kahn, R., Turkov, M., Stankiewicz, M., Stühmer, W., Dong, K. and Gordon, D. (2007) The insecticidal potential of scorpion beta-toxins. Toxicon, 49:473-489.
  87. Gordon, D., Karbat, I., Ilan, N., Cohen, L., Kahn, R., Gilles, N., Dong, K., Stühmer, W., Tytgat, J. and Gurevitz, M. (2007) The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control. Toxicon, 49:452-472.
  88. Karbat, I., Kahn, R., Cohen, L., Ilan, N., Gilles, N., Corzo, G., Froy, O., Gur, M., Albrecht, G., Heinemann, S.H., Gordon, D. and Gurevitz, M. (2007) The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail. FEBS J., 274:1918-1931.
  89. Moran, Y., Kahn, R., Cohen, L., Gur, M., Karbat, I., Gordon, D. and Gurevitz, M. (2007) Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na-channels. Biochem. J., 406:41-48.
  90. Cohen, L., Ilan, N., Gur, M., Stühmer, W., Gordon, D. and Gurevitz, M. (2007) Design of a specific activator for skeletal muscle voltage-gated sodium channels uncovers channel architecture. J. Biol. Chem., 282:29424-29430.
  91. Cohen, L., Troub, Y., Turkov, M., Gilles, N., Ilan, N., Benveniste, M., Gordon, D. and Gurevitz, M. (2007) Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant 'insect-selective' toxins when preconditioned. Mol. Pharmacol., 72:1220-1227.
  92. Schnur, E., Turkov, M., Kahn, R., Gordon, D., Gurevitz, M. and Anglister, J. (2008) NMR analysis of interaction of LqhaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect Para voltage-gated sodium channel. Biochemistry, 47:911-921.
  93. Moran, Y., Weinberger, H., Sullivan, J.C., Reitzel, A.M., Finnerty, J.R. and Gurevitz, M. (2008) 'Concerted Evolution' of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome. Mol. Biol. Evol., 25:737-747.
  94. Cohen, L., Lipstein, N., Karbat, I., Ilan, N., Gilles, N., Kahn, R., Gordon, D. and Gurevitz, M. (2008) Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated Na-channels. J. Biol. Chem., 283:15169-15176 (paper of the week).
  95. Moran, Y., Weinberger, H., Reitzel, A.M., Sullivan, J.C., Kahn, R., Gordon, D., Finnerty, J.R. and Gurevitz, M. (2008) Intron retention as a post-transcriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis. J. Mol. Biol., 380:437-443.
  96. Marcus, Y., Altman-Gueta, H., Snir, A., Wolff, Y. and Gurevitz, M. (2008) Does Rubisco limit the rate of photosynthesis? in 'Photosynthesis, Energy From The Sun (Allen, J.F., Gantt, E., Golbeck, J.H. and Osmond, B., eds.) 14th International Congress on Photosynthesis, pp. 867-871, Springer Verlag.
  97. Moran, Y., Weinberger, H., Lazarus, N., Gur, M., Kahn, R., Gordon, D. and Gurevitz, M. (2009) Fusion and retrotransposition events in the evolution of sea anemone neurotoxin genes. J. Mol. Evol., 69:115-124.
  98. Cohen, L., Moran, Y., Sharon, A., Segal, D., Gordon, D. and Gurevitz, M. (2009) Drosomycin, an innate immunity peptide of Drosophila, interacts with DmNav1 of the nervous system. J. Biol. Chem., 284:23558-23563.
  99. Kahn, R., Karbat, I., Ilan, N., Cohen, L., Gordon, D. and Gurevitz, M. (2009) Molecular requirements for specific recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J. Biol. Chem., 284:20684-20691.
  100. Moran, Y., Gordon, D. and Gurevitz, M. (2009) Sea anemone toxins affecting voltage-gated sodium channels - molecular and evolutionary features. Toxicon, 54:1089-1101.
  101.  Weinberger, H., Moran, Y., Kahn, R., Gordon, D. and Gurevitz, M. (2010) Positions under positive selection - key for selectivity and potency of scorpion a-toxins. Mol. Biol. Evol., 27:1025-1034.
  102. Paldi, T. and Gurevitz, M. (2010) Coupling between residues on S4 and S1 define the voltage sensor resting conformation in NaChBac. Biophys. J., 99:456-463.
  103. Karbat, I., Ilan, N., Zhang, J.Z., Cohen, L., Kahn, R., Benveniste, M., Scheuer, T., Catterall, W.A., Gordon, D. and Gurevitz, M. (2010) Partial agonist and antagonist activities of a mutant scorpion b-toxin on sodium channels. J. Biol. Chem., 285:30531-30538.
  104. Song, W., Du, Y., Liu, Z., Luo, N., Turkov, M., Gordon, D., Gurevitz, M., Goldin, A.L. and Dong, K. (2011) Mutations in the voltage sensor in domain III enhance the sensitivity of an insect sodium channel to a scorpion b-toxin. J. Biol. Chem., 286:15781-15788.
  105. Marcus, Y., Altman-Gueta, H., Wolff, Y. and Gurevitz, M. (2011) Mutagenesis at Rubisco active site impairs catalysis but hardly affects photosynthesis and growth of the cyanobacterium Synechocystis PCC6803. J. Exp. Bot., 62:4173-4182.
  106. Zhang, J.Z., Karbat, I., Cohen, L., Yarov-Yarovoy, V., Scheuer, T., Gordon, D., Gurevitz, M.  and Catterall, W.A. (2011) Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. J. Biol. Chem., 286:33641-33651.
  107. Wang, J., Yarov-Yarovoy, V., Kahn, R., Gordon, D., Gurevitz, M., Scheuer T. and Catterall W.A. (2011) Mapping the receptor site for a-scorpion toxins on a sodium channel voltage sensor. Proc. Natl. Acad. Sci. USA, 108:15426-15431.
  108. Gur, M., Kahn, R., Regev, N., Wang, J., Catterall, W.A., Gordon, D. and Gurevitz, M. (2011) Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core-domain of scorpion alpha-toxins on sodium channels. J. Biol. Chem., 286:35209-35217.
  109. Wang, J., Yarov-Yarovoy, V., Kahn, R., Gordon, D., Gurevitz, M., Scheuer, T. and Catterall, W.A. (2011) Molecular determinants for alpha-scorpion toxin binding to the resting state of a voltage sensor of brain sodium channels. Biophys. J., 100(3):1186-Pos., Board B272, DOI:10.1016/j.bpj.2010.12. 2498.
  110. Moran, Y., Genikhovich, G., Gordon, D., Technau, U. and Gurevitz, M. (2012) Localization of neurotoxins to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc. Royal Soc. B., 279:1351-1358.
  111. Gurevitz, M. (2012) Mapping the scorpion toxin receptor sites at voltage-gated sodium channels. Toxicon, 60:502-511.
  112. Zhang, J.Z., Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M., and Catterall, W.A. (2012) Mapping the Receptor Sites for a β-Scorpion Toxin on the Pore Module in Domain III of Voltage-Gated Sodium Channels. Biophys. J., 102(3):325a.
  113. Gur Barzilai, M, Reitzel, A.M., Eitel, M., Schierwater, B., Genikhovich, G., Technau, U., Gordon, D., Gurevitz, M., and Moran, Y. (2012) Convergent evolution of sodium selectivity in metazoan voltage-gated ion channels. Cell Rep., 2:242-248.
  114. Zhang, J.Z, Yarov-Yarovoy, V., Scheuer, T., Karbat, I., Cohen, L., Gordon, D., Gurevitz, M. and Catterall, W.A. (2012) Mapping the interaction site for a b-scorpion toxin in the pore module of domain III of voltage-gated sodium channels. J. Biol. Chem., 287:30719-30728.
  115. Ma, Z., Kong, J., Gordon, D., Gurevitz, M. and Kallen, R.G. (2013) Direct evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movements. PLoS One, 8(11):e77758, DOI:101371/Journal.Pone.0077758. collection 2013.
  116. Gao, R., Du, Y., Wang, L., Nomura, Y., Satar, G., Gordon, D., Gurevitz, M., Goldin, A.L. and Dong, K. (2014) Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. Neuroscience, 268:297-308.
  117. Gur Barzilai, M., Kahn, R., Regev, N., Gordon, D., Moran, Y. and Gurevitz, M. (2014) The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore region of target sodium channels. Biochem. J., 463:271-277.
  118. Gurevitz, M. (2014) An international high court for scientific debates is now required. Commentary to "Science ethics: young scientists speak". Science, 345:24-27.
  119. Gurevitz, M., Gordon, D., Gur Barzilai, M., Kahn, R., Cohen, L., Moran, Y., Zilberberg, N., Froy, O., Altman-Gueta, H., Turkov, M., Dong, K. and Karbat, I. (2015) Molecular description of scorpion toxin interaction with voltage-gated sodium channels. In: Toxinology: Scorpion Toxins: Scorpion venoms (Gopalakrishnakone, P., Ferroni Schwartz, E., Possani, L.D., Rodríguez de la Vega, R.C., Eds.), pp. 471-491, Springer.
  120. Marcus, Y. and Gurevitz, M. (2016) Ornidazole and related compounds to use as herbicides. US Patent US9237750B2 assigned to Ramot, Tel Aviv University.
  121. Gurevitz, M. and Altman-Gueta, Hagit (2016) The paradox of scorpion toxin interactions with portable Nav receptors. JSM Chemistry, 4(2):1023-1028. (Perspective).
  122. Marcus, Y., Tal, N., Ronen, M., Carmieli, R. and Gurevitz, M. (2016) The drug ornidazole inhibits photosynthesis in a different mechanism described for protozoa and anaerobic bacteria. Biochem. J., 473:4413-4426 and 474:4269.
  123. Karbat, I., Altman-Gueta H., Szanto, G.T., Hamer-Rogotner, S., Dym, O., Frolow, F., Gordon, D., Panyi, G., Gurevitz, M. and Reuveny, E. (2018) An allosteric action mechanism of a K+ pore blocker revealed at the atomic level. Biophys. J., 114(3):375 (1849-Plat)  (Supplementary).
  124. Karbat, I., Altman-Gueta H., Fine, S., Szanto, T., Hamer-Rogotner, S., Dym, O., Frolow, F., Gordon, D., Panyi, G., Gurevitz, M. and Reuveny, R. (2019) Pore-modulating toxins exploit inherent slow inactivation to block K+ channels. Proc. Natl. Acad. Sci. USA, 116:18700-18709.
  125. Marcus, Y. and Gurevitz, M. (2020) Ferredoxin-mediated reduction of 2-nitrothiophene inhibits photosynthesis: Mechanism and herbicidal potential. Biochem. J., 477:1149-1158, DOI:10.1042/BCJ20160433
  126. Gurevitz, M. (2020) The myth of the Corona monster. J. Pharmacol. Pharmaceut. Res., 3: 1-2 (Opinion).
  127. Gurevitz, M. (2020) Scientific individualism shrinks. Clin. Res. Trials, 6:1, DOI 10.15761/CRT.1000303 (Commentary).
  128. Zhorov, B., Du, Y, Song, W., Luo, N., Gordon, D., Gurevitz, M. and Dong, K. (2021) Mapping the interaction surface of scorpion b-toxins with an insect sodium channel. Biochem. J., 478:2843-2869.
  129. Gurevitz, M. (2021) Self-extinction on verge - an illogical reality. Intern. J. BioMed Res., 1:1, DOI:10.31579/IJBR-2021/002 (Perspective).
  130. Gurevitz, M. (2021) Grandson Beaten at Schoolyard for Support of Big Bang Theory. Intern. J. BioMed. Res., 6(2):142, DOI: 10:31579/2637 (Commentary).
  131. Gurevitz, M. (2021) Has World War III begun? J. Clin. Res. Rep., 7(2):146, DOI:10.31579/2641-0419/146 (Opinion).
  132. Zhu, Q., Du, Y., Nomura, Y., Gao, R., Cang, Z., Wei, G., Gordon, D., Gurevitz, M., Groome, J.R. and Dong, K. (2021) Charge substitutions at the voltage-sensing module of domain III enhance actions of site-3 and site-4 toxins on an insect sodium channel. Insect Biochem. Mol. Biol., 137(11):103625-103635, DOI:1016/j.ibmb.2021.103625
  133. Gurevitz, M. (2021) “Futile publications” - inevitable reality or a challenge. Eur. J. Appl. Sci., 9(6):296-297, DOI:10.14738/aivp.96.11188 (Commentary).
  134. Gurevitz, M. (2021) Where from may aliens pop in to Earth - a layman’s perspective. Eur. J. Appl. Sci., 11(2):731-732, DOI:10.14738/aivp.112.14432 (Opinion).
  135. Gurevitz, M. (2022) Antisemitism - a mirror to primitive brains. Arch. Busin. Res., 10(2): 15-16, DOI:10.14738/abr.102.2022 (Commentary).
  136. Gurevitz, M. (2022) Primitive male urges underlie women oppression. Eur. J. Appl. Sci., 10(2):228-229, DOI:10.14738/aivp.102.12049 (Opinion).
  137. Gurevitz, M. (2022) Human cruelty - a built-in default. J. BioMed. Sci., 4(2):1-2, DOI:10.38125 /OAJBS.000435 (Commentary).
  138. Gurevitz, M. (2022) Reputed intentions behind the Corona outbreak. J. BioMed. Sci., 4(2), 1792-1793, OAJBS.ID.000441, DOI:10.38125/OAJBS.000441 (Commentary).
  139. Gurevitz, M. (2022) Happiness - an evasive state of mind. Annals Depress. Anxiety, 9(1): 1114, DOI.Org./10.26420/anndepressanxiety.2022.1114 (Opinion).
  140. Gurevitz, M. (2022) Religion - a sophisticated strategy to gain control over the masses. Annal. Depress. Anxiety, 9(1):1115-1116, DOI.Org./10.26420/anndepressanxiety. 2022.1115 (Editorial).
  141. Gurevitz, M., Zhorov, B. S. and Dong, K. (2022) Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers. J. Neurobiol. Physiol., 4(1):9-12.
  142. Gurevitz, M. (2022) To end imperialistic aspirations Russia must be divided. Eur. J. Appl. Sci., 10(4):801-802, DOI:10.14738/aivp.104.12820 (Opinion).
  143. Gurevitz, M. (2022) What do the Iranian Ayatollahs really want. Eur. J. Appl. Sci., 10(5): 514-515, DOI:10.14738/aivp.105.13299 (Opinion).
  144. Gurevitz, M. (2022) Has humanity reached the stationary phase of its growth curve? Eur. J.  App. Sci., 10(5):169-170, DOI:10.14738/aivp.105.13152 (Commentary).
  145. Gurevitz, M. (2022) “ArduMania” - a syndrome of overblown arrogance. Eur. J. Appl. Sci., 10(6):27-28, DOI:10.14738/aivp.106.12819 (Commentary).
  146. Gurevitz, M. (2022) Deceptive claims rewrite the history of Canaan. Eur. J. Appl. Sci., 10(6):606-608, DOI:10.14738/aivp.106.13715 (Commentary).
  147. Gurevitz, M. (2023) Giant asteroid or nuclear winter - a 2023 menu. Eur. J. Appl. Sci., 11(1):40-41, DOI:10.14738/aivp.111.13766 (Commentary).
  148. Gurevitz, M. (2023) Spiritual enlightening and ‘clockwork orange’ coexist in human brains. J. Clinical Res. Notes, 4(1):93-94, DOI:10.31579/2690-8816/093 (Commentary).
  149. Gurevitz, M. (2023) The rise and fall of Homo sapiens. Am. J. Biomed. Sci. & Res., 18(1):867-868, DOI:10.34297/AJBSR.2023.18.002449 (Commentary).
  150. Gurevitz, M. (2023) An international high court for ethics in science is now required. Eur. J. Appl. Sci., 11(2):189-191, DOI:10.14738/aivp.112.14055 (Opinion).
  151. Gurevitz, M. (2023) The gap between public perception and scientific advancements endangers humanity. Eur. J. Appl. Sci., 11(2):189-191, DOI:10.14738/aivp.112.14546 (Opinion).
  152. Gurevitz, M. (2023) The critical role of a positive self-esteem. Eur. J. Appl. Sci., 11(4):173-174, DOI:10.14738/aivp.114, 14856 (Opinion).
  153. Gurevitz, M. (2023) The border between science and science-fiction is fading out. Eur. J. Appl. Sci., 11(4):238-240, DOI:1014738/aivp.114.15194 (Opinion).
  154. Gurevitz, M. (2023) ‘Being there’ - a satiric criticism of human naivety now playing in Israel. Intern. J. Med. Case Rep. Med. Res., 1(2):1-2, DOI:10.61148/2994-6905/ IJMCRMR/014 (Commentary).
  155. Gurevitz, M. (2023) Leaders nearing the end of their career may endanger humanity. Eur. J. Appl. Sci., 1(5):366-368, DOI:10.14738/aivp.115.15338 (Opinion).
  156. Gurevitz, M. (2023) The ultimate revenge of Benjamin Netanyahu. Eur. J. Appl. Sci., 11(5): 369-372, DOI:10.14738/aivp.115.15558 (Commentary).
  157. Gurevitz, M. (2023) The creation of God in the mind of mankind - a spiritual need or hiding in a cave. Eur. J. Appl. Sci., 11(6):145-146, DOI:10.14738/aivp.116.15862 (Opinion).
  158. Gurevitz, M. (2023) Why do we owe our life to photosynthesis? Eur. J. Appl. Sci., 11(6): 211-212, DOI:10.14738/aivp.116.16044 (Commentary).
  159. Gurevitz, M. (2024) Historical irony - the greatest risk to the Israeli state is instigated by its religious sector. Eur. J. Appl. Sci., 12(1):268-269, DOI:10.14738/aivp.121.16382 (Commentary).
  160. Gurevitz, M. (2024) Future Prospects of the Human Familial Frame. Arch. Busin. Res., 12(2):1-2, DOI:10.14738/abr.122.16238 (Commentary).
  161. Gurevitz, M. (2024) Innocence and trust - forgotten concepts or nuisances? Eur. J. Appl. Sci., 12(2):357-358, DOI:10.14738/aivp.122.16646 (Commentary).
  162. Gurevitz, M. and Dagan, R. (2024) Colonizing other life-supporting planets: an unrealistic fantasy. Eur. J. Appl. Sci., 12(2):359-361, DOI:10.14738/aivp.122.16865 (Commentary).
  163. Gurevitz, M. and Dagan, R. (2024) The creation of the world - A galactic event beyond human grasp. Eur. J. Appl. Sci., 12(4):81-84, DOI:10.14738/aivp.124.17026 (Commentary).
  164. Gurevitz, M. and Dagan, R. (2024) Telepathic proficiency - A factual threat on humanity. Eur. J. Appl. Sci., 12(4):85-86, DOI:10.14738/aivp.124.17090 (Commentary).
  165. Gurevitz, M. (2024) The unimaginable conversion of paradise into hell. Eur. J. Appl. Sci., 12(4):238-240, DOI:10.14738/aivp.124.17343 (Commentary).
  166. Gurevitz, M. and Dagan, R. (2024) Pushing over the edge may lead to an unprecedented response. Eur. J. Appl. Sci., 12(4):233-237, DOI:10.14738/aivp.124.17323 (Commentary).
  167. Gurevitz, M. (2024) The superiority of Buddhism over the three monotheistic religions. Eur. J. Appl. Sci., 12(4):233-237, DOI:10.14738/aivp.124.17323 (Commentary).
  168. Gurevitz, M. (2024) The self-conviction in God’s selection - a fading myth. Eur. J. Appl. Sci., 12(5):409-410, DOI:10.14738/aivp.125.17539 (Commentary).
  169. Gurevitz, M. (2024) Nullification of radical religious and national aspirations is critical for survival of humanity. Eur. J. Appl. Sci., 12(5):274-276, DOI:10.14738/aivp.125.17670.  (Commentary).
  170. Gurevitz, M. (2025) Ali Khamenei - a criminal in disguise. Eur. J. Appl. Sci., 13(1):43-45, DOI:10.14738/aivp.131.17795 (Commentary).
  171. Gurevitz, M. (2025) The forthcoming freezing of the European west coast is seemingly a ‘Divine Retribution’. Eur. J. Appl. Sci., 13(1):40-42, DOI:10.14738/aivp.13118061 (Commentary).
  172. Gurevitz, M. (2025) Putative roots of the embellished ego of Russian leaders. Eur. J. Appl. Sci., 13(1):138-141, DOI:10.14738/aivp.131.18182 (Commentary).
  173. Gurevitz, M. (2025) Our toughest enemy is TIME.  Eur. J. Appl. Sci., 13(3):17-18, DOI:10.14738/aivp.1303.18520 (Commentary).
  174. Gurevitz, M. (2025) Don’t Mess Up: Zionism Reflects Legitimate Longing to the Ancient Homeland. Eur. J. Appl. Sci., 13(3):26-33, DOI:10.14738/aivp.1303.18777 (Commentary).
  175. Gurevitz, M. (2025) Our vulnerability to catastrophes and our evolutionary stage are inversely related. Eur. J. Appl. Sci., 13(4):47-48, DOI:10.14738/aivp.1304.19027  (Opinion).
  176. Gurevitz, M. (2025) The central role of music in our life. Eur. J. Appl. Sci., 13(4), 43-46, DOI:10.14738/aivp.1304.19098 (Commentary).
  177. Gurevitz, M. (2025) What would Tasmanian devils say about humans if they could. Eur. J. Appl. Sci., Submitted.
  178. Gurevitz, M. (2025) Megalomaniac aspirations to revive empire days should be obstructed early. Eur. J. Appl. Sci., Submitted.
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