ד"ר אילה למפל

Dr. Ayala Lampel is an assistant professor (senior lecturer) in the School of Molecular Cell Biology and Biotechnology since 2019. She obtained a B.Sc. in Neuroscience and a PhD in Biotechnology from Tel Aviv University.

Education:

2015-2019       Postdoctoral fellow, Nanoscience Initiative, Advanced Science Research Center, City University of New York

2009-2014       Ph.D., Direct track in Biotechnology, Department of Molecular Microbiology and Biotechnology, Tel Aviv University

2005-2008       B.Sc., Neuroscience, Tel Aviv University

Academic appointments:

2019       Assistant Professor, Tel Aviv University

Biological systems use a precise control in space and time to form functional materials, however, their dynamic properties are not yet accessible in man-made biomaterials. Our vision is to fill this gap by studying the manufacturing process of biological materials used in nature and applying these insights into design tools for biomaterials.

Specific interests:

• Compartmentalization of enzymatic reactions in synthetic organelles;
• Molecular self-assembly of ordered/disordered peptide and protein structures and their biophysical characterization;
• Design rules of peptide assemblies as models for membraneless organelles;
• Design of dynamic bioreactors formed by multicomponent peptide-based building blocks;

Lampel, A., Tuttle, T., Ulijn, R.V. Guiding principles for peptide nanotechnology through directed discovery. Chemical Society Reviews. 2018, 47, 3737-3758.

Zhang, C., Shafi, R., Lampel, A., MacPherson, D., Pappas, C. G., Wang, T.,  Maldarelli C., Ulijn, R. V. Switchable Hydrolase Based on Reversible Formation of Supramolecular Catalytic Site Using a Self‐Assembling Peptide. Angewandte Chemie International Edition. 2017, 129, 14703-14707.

Lampel, A., McPhee S. A., Park, H.-A. Scott, G. G., Humagain, S., Hekstra, D. R., Yoo, B., Frederix P. W. J. M., Li, T.-D., Abzalimov R. R., Greenbaum S. G., Tuttle, T., Chunhua H., Bettinger, C. J., Ulijn, R. V. Polymeric peptide pigments with sequence-encoded properties. Science 2017, 356, 1064-1068.

Alakpa, E. V., Jayawarna, V., Lampel, A., Burgess, K. V., West, C. C., Bakker, S. C.J, Roy, S., Javid, N., Fleming, S., Lamprou, D. A., Yang, J., Miller, A., Urquhart, A. J, Frederix, P. W.J.M., Hunt, N. T, Péault, B., Ulijn, R. V., Dalby, M. J. Tunable supramolecular hydrogels for selection of lineage guiding metabolites in stem cell cultures. Chem 2016, 1, 298-319.

Lampel, A., Varenik M., Regev O., Gazit, E. Hierarchical multi-step organization during viral capsid assembly. Colloids and Surfaces B: Biointerfaces 2015, 136, 674-677.

Mondal, S*., Adler-Abramovich, L*., Lampel, A., Bram, Y., Lipstman, S., Gazit, E. Formation of functional super-helical assemblies by constrained single heptad repeat. Nature Communications 2015, 6.

Lampel, A., Bram, Y., Ezer A., Shaltiel-Kario R., Saad, J. S., Bacharach, E., Gazit, E. Targeting the early step of building block organization in viral capsid assembly. ACS Chemical Biology 2015, 10, 1785-1790.

Lampel, A., Elis E., Guterman, T., Shapira S., Marco, P., Bacharach, E., Gazit, E. α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments. Chemical Communications 2015, 51, 12349-12352.

Bram, Y., Lampel, A., Shaltiel-Karyo, R., Ezer, A., Scherzer-Attali, R., Segal, D., Gazit, E. Monitoring and targeting the initial dimerization stage of amyloid self-assembly. Angewandte Chemie International Edition 2014, 54, 2062-2067.

Lampel, A., Yaniv, O., Berger, O., Bacharach, E., Gazit, E., Frolow, F. A triclinic crystal structure of the carboxy-terminal domain of HIV-1 capsid protein with four molecules in the asymmetric unit reveals a novel packing interface. Acta Crystallographica Section F 2013, F69, 602-606.

Lampel, A., Bram, Y., Levy-Sakin, M., Bacharach, E., Gazit, E. The effect of chemical chaperones on the assembly and stability of HIV-1 capsid protein. PLOS ONE 2013, 8(4): e60867.

Frydman-Marom, A., Convertino, M., Pellarin, R., Lampel, A., Shaltiel-Kario, R., Caflisch, C., Shalev, E. D., Gazit, E. Structural basis for inhibiting β-amyloid oligomerization by a non-coded β-breaker-substituted endomorphin analogue. ACS Chemical Biology 2011, 6, 1265-1276.