פרופ' אריאל מוניץ

סגל אקדמי בכיר במיקרוביולוגיה ואימונולוגיה קלינית
מיקרוביולוגיה ואימונולוגיה קלינית סגל אקדמי בכיר
פרופ' אריאל מוניץ
טלפון פנימי: 03-6407636
טלפון נוסף: 03-6407635
פקס: 03-6407635
משרד: רפואה-סאקלר, 810

Positions

2013-present    Associate Professor, Department of Microbiology and Clinical Immunology, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
2014- present   Director, Ella Kodesz Institute of Host Defense against Infectious Diseases
2009 - 2013 Senior Lecturer (Assistant Professor), Department of Microbiology and Clinical Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
2009 - 2012   Adjunct Assistant Professor, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

 

קורות חיים

לימודים:

   1999-2001-           תואר ראשון במדעי הרפואה הבסיסיים, המכון למדעי הרפואה, הפקולטה לרפואה, האוניברסיטה העברית ירושלים

2001-2006-              מסלול ישיר לדוקטורט בפרמקולוגיה, הפקולטה לרפואה, האוניברסיטה העברית ירושלים

תעסוקה:

2006-2009-              פוסטדוקטרוט במחלקה לאלרגיה ואימונולוגיה, בית החולים לילדים בסינסינטי, אוהיו, ארה״ב

2009-2013               מרצה בכיר, המחלקה למיקרוביולוגיה ואימונולוגיה קלינית, בית הספר לרפואה על שם סאקלר, אוניברסיטת תל אביב

2013-2018               פרופסור חבר, המחלקה למיקרוביולוגיה ואימונולוגיה קלינית, בית הספר לרפואה על שם סאקלר, אוניברסיטת תל אביב

2018- כיום                 פרופסור מן המניין, המחלקה למיקרוביולוגיה ואימונולוגיה קלינית, בית הספר לרפואה על שם סאקלר, אוניברסיטת תל אביב

 

 

 

תחומי מחקר

מטרת המעבדה שלנו היא לזהות מנגנונים אשר מבקרים את הפעילות של תאים ממערכת החיסון במצבי בריאות וחולי. עיקר ההתמקדות שלנו היא במחלות דלקתיות כרוניות וסרטן

על מנת להשיג את המטרה הזו, אנו נעזרים במגוון שיטות הכוללות עבודה עם עכברים טרנסגניים ייחודיים, תרביות תאים ורקמה, ביוכימיה, ופרוטאומיקה וביולוגיה מולקולרית. 

 

 

פרסומים

Peer-reviewed papers 

1.             Reichman H, Itan M, Rozenberg P, Yarmolovski T, Brazowski E, VarolC, Gluck N, Shapira S, Arber N, Qimron U, Karo-Atar D, LeeJJ, Munitz A. Activated eosinophils exert distinct anti-tumorigenic activities in colorectal cancer. Cancer Immunol Res. 2018; In Press

2.             Shlomovitz I, Erlich Z, Speir M, Zargarian S, Baram N, Edry-Botzer L, MunitzA, Croker BA, Gerlic M.Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model. FEBS.2018; In Press

3.             Lee EH, Itan M, Jang J, Gu HJ, Rozenberg P, Mingler MK, Wen T, Yoon J, Park SY, Roh JY, Choi CS, Park WJ, Munitz A, Jung Y. Eosinophils support adipocyte maturation and promote glucose tolerance in obesity.Sci Rep. 2018;8:9894. doi: 10.1038/s41598-018-28371-4.

4.             Grace JO, Malik M, Reichman H, Munitz A, Barski A, Fulkerson PC. Reuse of public, genome-wide, murine eosinophil expression data for hypotheses development. J Leuk Biol.2018: 2018: doi: 10.1002/JLB.1MA1117-444R

5.             Salamon P, Shefler I, Moshkovits I, Munitz A, Klotzman HK, Mekori Y, Hershko A. IL-33 and IgE stimulate mast cell production of IL-2 and regulatory T cell expansion in allergic dermatitis. Clin Exp Allergy. 2017: 47; 1409-1416. 

6.             Reichman H, Moshkovits I, Itan M, Pasmanik-Chor M, Vogl T, Roth J, Munitz A. Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing. Sci Reports.2017; 7:7117. doi: 10.1038/s41598-017-07738-z.

7.             Rozenberg P, Reichman H, Zab-Bar I, Itan M, Pasmanik-Chor M, BouffiC, QimronU, Bachelet I, Fulkerson PC, Rothenberg ME, MunitzA. CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production. Sci Reports. 2017; 7:5922. doi: 10.1038/s41598-017-06397-4.

8.             Amit U, Kain D, Wagner A, Sahu A, Nevo-Caspi Y, Gonen N, Molotski N, Konfino T, Landa N, Naftali-Shani N, Blum G, Merquiol E, Karo-Atar D, Kanfi Y, Paret G, Munitz A, Cohen HY, Ruppin E, Hannenhalli S, Leor J. A New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure. J Am Heart Ass. 2017: 6(5). pii: e005108. doi: 10.1161/JAHA.116.005108.

9.             Goldman SF, Moshkovits I, Filiba A, Tsirulsky Y, Shemesh A, Vronov E, Shagan M, Apte RN, Benharroch D, Karo-Atar D, Dagan R, Munitz A, Mizrachi Nebenzahl Y, Porgador A. Natural killer receptor 1 dampens the development of allergic eosinophilic airway inflammation. PLoS One. 2016:11;e0160779(doi: 10.1371/journal.pone.0160779).

10.          Moshkovits I, Reichman H, Karo-Atar D, Rozenberg P, Zigmond E, Ziv-Haberman Y, Ben-Baruch-Morgenstern N, Lampinen M, Carlson M, Itan M, Denson LA, Varol C, Munitz A.A key requirement for CD300f in innate immune responses of eosinophils in colitis. Mucosal Immunol. 2017 Jan;10(1):172-183. doi: 10.1038/mi.2016.37

11.          Yosef I, Edgar R, Levy A, Sorek R, Munitz A, Qimron U. Natural selection acts alone to give the appearance of "stress-induced" mutagenesis.Nature Microbiol. 2016:1;6047s.(doi: 10.1038/nmicrobiol.2016.47)

12.          Ben-Baruch-Morgenstern N, MinglerMK, StuckeEM, Besse JA, WenT, Reichman H, Munitz A*Rothenberg ME*. Paired immunoglobulin-like receptor B inhibits IL-13–driven eosinophil accumulation and activation in the esophagus. J Immunol. 2016;197:707-14.(*-Equal contribution).

13.          Caspi M, Firsow A, Rajkumar R, Skalka N, Moshkovitz I, Munitz A, Pasmanik-Chor M, Greif H, Megido D, Kariv R, Rosenberg DW, Rosin-Arbesfeld R. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents. J Mol Med. 2015[Epub ahead of print]

14.          Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA. Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair. Immunity. 2015;43(4):803-16.

15.          Moshkovits I, Karo-Atar D, Shik D, Reichman H, Itan M, Ejarque-Ortiz A, Hershko AY, Tian L, Coligan JE, Sayos J, Munitz A. CD300f associates with IL-4 receptor and is required for IL-4-induced cellular responses. Proc Natnl Acad Science USA; 2015:112;8708-13.

16.          Karo-Atar D, Bordowitz A, Wand O, Pasmanik-ChorM, FernandezI E, ItanM, Frenkel R, HerbertDR, Eickelberg O, MunitzA.A protective role for IL-13 receptor a1 in bleomycin-induced pulmonary fibrosis. Mucosal Immunol2016 Jan;9(1):240-53. doi: 10.1038/mi.2015.56

17.          Karo-Atar D, Itan M, Pasmanik-Chor M, Munitz A.MicroRNA profiling reveals opposing expression patterns for miR-511 in alternatively and classically activated macrophages. J Asthma. 2014: 18:1-25

18.          Shik D, Moshkovits I, Karo-Atar D, Reichman H, Munitz A. IL-33 requires CMRF35-like molecule 1 (CLM-1) expression for induction of myeloid cell activation. Allergy2014:69;719-29.

19.          Ben Baruch-Morgenstern N, Shik D, Moshkovits I, Itan M, Karo-Atar D, Bouffi C, Fulkerson PC, Rashkovan D, Jung S, Rothenberg M, Munitz A.  Paired immunoglobulin-like receptor A is an intrinsic, self-limiting pathway suppressing IL-5-induced eosinophil development. Nat Immunol. 2014:36-44.

20.          Moshkovits I, Shik D, Itan M, Karo-Atar D, Bernshtein B, Hershko AY, van Lookeren Campagne M, Munitz A. CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis.Mucosal Immunol;2014:7;292-303.

21.          Karo-Atar D, Moshkovits I, Eickelberg O, Königshoff M, Munitz A. PIR-B regulates pulmonary fibrosis by suppressing profibrogenic properties of alveoalar macrophages.Am J Res Cell Mol Biol. 2013; 48:456-464.

22.          Semis R, Shai N, Munitz, A, Zaslavsky Z, Polacheck I, Segal E.Pharmacokinetics, tissue distribution and immunomodulatory effect of intralipid formulation of nystatin in mice. J of Antimicrob Chem;2012;67:1716-21.  

23.          Munitz A, Cole ET, Karo-Atar D, Finkelan FD, Rothenberg ME. Resistin-like molecule alpha regulates IL-13-induced chemokine production but not allergen-induced airway responses. Am J Res Cell Mol Biol2012;46:703-13.

24.          Rothenberg ME, Cole ET, Shik D, Mingler MM, Munitz A. IL-13 receptor 1 differentially regulates aeroallergen induced lung responses. J Immunol2011187:4873-80.

25.          Waddell A, Ahrens R, Steinbrecher K, Donovan B, Rothenberg ME, Munitz A, Hogan SP. Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol.2011;186:5993-6003.

26.          Munitz A, Cole ET, Waddell A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis. Gastroenterology2010;139:530-41.

27.          Herbert DR, Wang JQ, Hogan SP, Groshwitz K, Khodoun M, Munitz A, Orekov T, Perkins C, Wang Q, Brombacher F, Urban Jr. JF, Rothenberg ME, and Finkelman FD. IL-4 and IL-13 protect against intestinal worms by inducing epithelial cells to secrete RELM-b. J Exp Med. 2009; 206:2947-57.

28.          Munitz A, Seidu L, Ahrens R, Cole E, Hogan SP, Rothenberg ME. Resistin-like molecule adecreases glucose tolerance during intestinal inflammation. J Immunol. 2009;182:2357-63.

29.          Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol. 2009;182:4994-5002.

30.          Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-30.

31.          Nissim Ben Efraim AH, Munitz A,S herman Y, Mazer BD, Levi-Schaffer F, Eliashar R. Efficient purification of eosinophils from human tissues: A comparative study. J Immunol Methods.2009;343:91-6.

32.          Munitz A, Beichler A, Seidu L, Ahrens R, Cole E, Hogan SP, Rothenberg ME. Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis. J Allergy Clin Immunol.2008;122:1200-1207.

33. Munitz A, McBride ML, Bernstein JB, Rothenberg ME. A dual activation and inhibition role for the paired immunoglobulin-like receptor B (PIR-B) in eosinophils.Blood2008;111(12):5694-703.

34.          Munitz A, Brandt EB, Mingler M, Finkelmen FD, Rothenberg ME. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha 1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A.2008105:7240-5. 

35.          Ahrens R, Beichler A, Seidu L, Blanchard C, Carey R, Forbes E, Wilson T,  Cohen E, Ballard E, Munitz A, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Macrophage/Intestinal epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in Pediatric Ulcerative Colitis. J Immunol. 2008;181:7390-9

36.          Brandt EB, Munitz A, OrekovT, Mingler MK, McBride M, Finkelman FD, Rothenberg ME. Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea. J Allergy Clin Immunol.2008;122:1200-1207

37.          Bachelet I, Munitz A, Berent-Maoz B, Mankuta D, Levi-Schaffer F. Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a. J Immunol2008. 180:6064-9.

38.          Munitz A, Bachelet I, Finkelman FD, Rothenberg ME, Levi-Schaffer F. CD48 is critically involved in allergic eosinophilic airway inflammation. Am J Respir Crit Care Med. 2007;175:911-8.

39.          Munitz A, Bachelet I, Moretta A, Moretta L, Levi-Schaffer F. The Inhibitory receptor IRp60 suppresses the effects of eotaxin and IL-5/GM-CSF on human eosinophils. Blood.2006;107:1996-2003.

40.          Munitz A, Bachelet I, Eliashar R, Khodoun M, Finkelman FD, Rothenberg ME, Levi-Schaffer F. CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J Immunol.2006;177:77-83.

41.          Bachelet I, Munitz A, Mankuta D, Levi-Schaffer F. Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic processJ Biol Chem.2006;281(37):27190-6.

42.          Munitz A, Bachelet I, Levi-Schaffer F. Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a. J Allergy Clin Immunol.2006;118:1082-9. 

43.          Bachelet I*Munitz A*, Levi-Schaffer F. Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J Allergy Clin Immunol. 2006;117(6):1314-20. 

*-Equal contribution.

44.          Bachelet I*, Munitz A*, Moretta A, Moretta L, Levi-Schaffer F. The Inhibitory receptor IRp60 is expressed and functional on human mast cells. J Immunol2005;175:12:7989-95.
*-Equal contribution.

45.          Munitz A, Bachelet I, Fraenkel S, Katz G, Mandelboim O, Simon Hans Uwe, Moretta Lorenzo, Colonna Marco, Levi-Schaffer F. 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol2005;174:110-8.

 

Peer-reviewed reviews

1.             Karo-Atar D, Bitton A, Benhar I, Munitz A.Therapeutic Targeting of the Interleukin-4/Interleukin-13 Signaling Pathway: In Allergy and Beyond. BioDrugs. 2018: doi: 10.1007/s40259-018-0280-7. 

2.             Rozenberg P, Reichman H, Moshkovits I, Munitz A. CD300 family receptors regulate eosinophil survival, chemotaxis and effector functions. J Leuk Biol. 2017:doi:10.1002/JLB.2MR1117-433R

3.             Reichman H, Karo-Atar D, Munitz. A. Eosinophils: “underdogs” of the tumor microenvironment. Trends in Cancer. 2016; 2:664-675.DOI: http://dx.doi.org/10.1016/j.trecan.2016.10.002.

4.             Stein M, Munitz A.Targeting interleukin 5 in asthma and hypereosinophilic syndromes. Recent Pat on Inflamm Allergy Drug Discov. 2010:4;201-9.

5.             Shik D, Munitz A. Inhibitory receptors in activation and suppression of the immune response”. Clin Exp Allergy.2010:40; 700-709

6.             Munitz A. Inhibitory receptors on myeloid cells: new targets for therapy? Pharmacol Ther. 2010:125; 128-37.

7.             Munitz A,Levi-Schaffer F. Targeting inhibitory receptors on eosinophils: a direct hit to the Achilles heel. J Allergy Clin Immunol2007;119:1382-7.

8.             Bachelet I, Munitz A, Levi-Schaffer F. Tryptase as an inflammatory marker in allergic disease and asthma. Expert Rev Clin Immunol.2005:1;63-73.

9.             Munitz A, Levi-Schaffer F. Eosinophils: ”new” roles for “old” cells. Allergy.2003;59:268-275.

 

Editorials

1.             Munitz A, Hogan SP. Alarming eosinophils to combat cancer.Nat Immunol. 2019;20:250-252. doi: 10.1038/s41590-019-0318-0

2.             Karo-Atar D, Munitz A.Is Asthma Paying the Toll? Am J Res Cell Mol Biol. 2018;58:3-4. doi: 10.1165/rcmb.2017-0288ED

3.             Rosenberg HF, Fryer AD, Munitz A, Bochner BS, Jacoby DB, Levi-Schaffer F, Gleich GJ, Furuta GT, Rothenberg ME, Lacy P, Fulkerson PC, Hogan SP, Ackerman SJ, Foster PS. In Memory and Celebration: Dr. James J. Lee. Clin Exp Allergy.2017 May 26. doi: 10.1111/cea.1295

4.             Reichman H, Munitz A.Research Highlight: Harnessing Class II Histone Deacetylases in Macrophages to Combat Breast Cancer. Cell Mol Immunol. 2017:14:575-577. doi: 10.1038/cmi.2017.32.

5.             Munitz A, Karo-Atar D, Foster PS. Asthma Diagnosis: miRNA’s to the rescue. J Allergy Clin Immunol. 2016.

6.             Munitz A, Foster PS. Th9 cells: Above and beyond Th2. J Allergy Clin Immunol. 2012;129:1011-3.

7.             Lacy P, Munitz A.Mutations in CCR3 render it “missing in action”. J Allergy Clin Immunol. 2010:126:158-9.

 

Book chapters

1.             Reichman H. Rozenberg P.Munitz A. “The identification, isolation and analysis of function for mouse eosinophils”. InCurrent Protocols in Immunology (Wiley, ed. Coligan JE), 2017;119:14.43.1-14.43.22. doi: 10.1002/cpim.35.

2.             Munitz A. Eosinophil Receptor-Mediated Inhibition. InEosinophils in health and in disease. (Elsevier, ed. Lee JJ and Rosenberg HF), 2013; pp. 179-188).

Bachelet I, Munitz A, Levi-Schaffer F. Co-culture of mast cells and fibroblasts: a tool to study their cross-talk, Methods Mol Biol2006:315;295-317.
אוניברסיטת תל אביב עושה כל מאמץ לכבד זכויות יוצרים. אם בבעלותך זכויות יוצרים בתכנים שנמצאים פה ו/או השימוש
שנעשה בתכנים אלה לדעתך מפר זכויות, נא לפנות בהקדם לכתובת שכאן >>