| The MHC functions to keep immune responses limited to non-self antigens. There is genetic variability among persons, and the various alleles are known as human leukocyte antigens (HLA) because they were first described in relation to transplantation tissue typing performed on peripheral white blood cells. The genes for the HLA system are located on chromosome 6. |
| There are MHC class 1 genes and MHC class 2 genes. MHC class 1 consists of the A, B, and C loci. MHC class 2 consists of the DR, DQ, and DP loci. One allele for each gene is inherited from each parent. The clinically relevant loci are A, B, and DR. |
| Class 1 MHC molecules are found on all nucleated cells in the body. Class 2 molecules are found only on antigen presenting cells, such as dendritic cells and macrophages, and on B cells. |
Based upon the following HLA tissue typing, who is a parent and who is the baby?
A11 B19
A23 B17 | A15 B19
A15 B35 | A15 B17
A23 B19 |
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