The Felsenstein Medical Research Center
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Laboratory of Cardiac Research

Head of Laboratory: Dan Aravot M.D.

Head of Research Group: Edith Hochhauser Ph.D.

  Tel: 972-3-9376789
Fax: 972-3-9211478
E-mail: hochhaus@post.tau.ac.il

Research Topics

  1. The influence of caloric restriction on cardiac performance following ischemic injury

  2. Cardiac dysfunction in septic shock and myocardial ischemia: the role of myocardial Toll-Like Receptor 4

  3. The implications of exercise training on cardiomyopathy and catecholamine-dependent polymorphic ventricular tachycardia (CPVT) in calsequestrin deficient mice

  4. The role of cannabinoid receptors in the regulation of cardiac tolerance to ischemia and reperfusion

  5. Reduced HO1 and adiponectin levels in diabetic patients may cause vascular and cardiac dysfunction

Selected Publications

  1. Cohen R, Shainberg A, Hochhauser E, Cheporko Y, Tobar JA, Birk E, Pinhas L, Leipziger J, Don J, Porat E. UTP reduces infarct size and improves mice heart function after myocardial infarct via P2Y(2) receptor. Biochem Pharmacol. 82(9):1126-33, 2011. MEDLINE

  2. Avlas O, Fallach R, Shainberg A, Porat E, Hochhauser E. Toll-like receptor 4 stimulation initiates an inflammatory response which decreases cardiomyocyte contractility. Antioxid Redox Signal. 5(7):1895-909, 2011. MEDLINE

  3. Kurtzwald-Josefson E, Hochhauser E, Katz G, Porat E, Seidman JG, Seidman CE, Chepurko Y, Shainberg A, Eldar M, Arad M. Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice. J Appl Physiol. 113(11):1677-83, 2012. MEDLINE

  4. Barzelay A, Hochhauser E, Entin–MeerM, Chepurko Y, Birk E, Afek A, Barshack I, Pinhas L, Revo Y, Ben-Shoshan J, Maysel-Auslender S, Keren G, George J. Islet-1 gene delivery improves myocardial performance after experimental infarction. Atherosclerosis 223(2):284-90, 2012. MEDLINE

  5. Issan Y, Hochhauser E, Kornowski R, Leshem-Lev D, Lev E, Sharoni R, Vanella L, Puri N, Laniado-Schwartzman M, Nader Abraham G. and Porat E. Endothelial progenitor cell function inversely correlates with long term glucose control in diabetic patients: association with attenuation of heme oxygenase -adiponectin axis, Canadian Journal of Cardiology, 2012 Mar 23. [Epub ahead of print] MEDLINE