Laboratory of Cellular and Molecular Cardiology

Head of Laboratory: Gania Kessler-Icekson, Ph.D.

	Tel:	972-3-937 6806/7291
	Fax:	972-3-9211478
	E-mail:	icekson@post.tau.ac.il

Research Topics

1. Characterization and regulation of the novel cardiac restricted Popeye domain containing (Popdc) gene family.

2. The cardioprotective effect of prior exercise training.

3. Regulation of cardiac fibrosis.

4. Development of new pharmacological tools for cardiac protection.

Selected Publications

1. Tarasenko N, Kessler-Icekson G, Boer P, Inbal A, Schlesinger H, Phillips DR, Cutts SM, Nudelman A, Rephaeli A. The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity. Invest New Drugs, Published online: 30:130–143, 2012 23 September 2010

2. Kessler-Icekson G, Hochhauser E, Sinai T, Kremer A, Dick J, Tarasenko N, Nudelman V, Schlesinger H, Abraham S, Nudelman A, Rephaeli A. A histone deacetylase inhibitory prodrug - Butyroyloxymethyl diethyl phosphate - Protects the heart and cardiomyocytes against ischemia injury. Eur J Pharmaceut Sci. 45(5):592-9, 2012. MEDLINE

3. Tarasenko N, Cutts SM, Phillips DR, Inbal A, Nudelman A, Kessler-Icekson G, Rephaeli A. Disparate impact of butyroyloxymethyl diethylphosphate (an-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor. PLoS One. 7(2):e31393, 2012. MEDLINE

4. Gabbay-Benziv R, Ao A, Fisch B, Zhang L, Oron G, Kessler-Icekson G, Ben-Haroush A, Krissi Haim, Abir R. Vasoactive intestinal peptide and its receptors in human ovarian cortical follicles. PLoS ONE 7(5):e37015, 2012. MEDLINE

5. Oron G, Fisch B, Zhang XY, Gabbay-Benziv R, Kessler-Icekson G, Krissi H, Ben-Haroush A, Ao A, Abir R. Fibroblast growth factor 10 in human ovaries. Reproductive BioMedicine Online (2012) 25, 396- 401. MEDLINE