Using two extremely different models of glass formers in two and three dimensions we demonstrate how to encode the subtle changes in the geometric rearrangement of particles during the scenario of the glass transition. We construct a statistical mechanical description that is able to explain and predict the geometric rearrangement, the temperature dependent thermodynamic functions and the α-relaxation time within the measured temperature range and beyond. The theory is based on an up-scaling to proper variables (quasi-species) which is validated using a simple criterion. Once constructed, the theory provides an accurate predictive tool for quantities like the specific heat or the entropy at temperatures that cannot be reached by measurements.