Laboratory of Cellular Endocrinology

Head of Laboratory: Ruth Koren, Ph.D.

	Tel:	972-3-9377394
	Fax:	972-3-9211478
	E-mail:	rkoren@post.tau.ac.il

Research Topics

The role of the epidermal vitamin D endocrine system in regulation of the cutaneous response to environmental and pathophysiological stresses:

1. The effects of hormonally active derivatives of vitamin D on epidermal cell death

2. The effects of hormonally active derivatives of vitamin D on the inflammatory response of the epidermis to various environmental and pathological challenges

3. The effects of hormonally active derivatives of vitamin D on tissue remodeling in the epidermis.

4. The effect of environmental and pathophysiological stresses on the synthesis and degradation of and the response to the hormonal form of vitamin D. calcitriol.

5. The effects of hormonally active derivatives of vitamin D on keratinocyte migration (related to wound healing)

Selected publications

1. Bahar-Shanny K, Ravid A , Koren R. Vitamin D inhibits the induction of MMP-9 by TNF in keratinocytes. Inflamm. Res. 56: Suppl 3 S395, 2007.

2. Ravid A, Ziv E, Koren R. Cross talk of Vitamin D and TNF on ERK activation in keratinocytes. Inflamm. Res. 56: Suppl 3 S425, 2007.

3. Miodovnik M, Koren R, Ravid A.Vitamin D attenuates the keratinocyte inflammatory response to TNF. Inflamm. Res. 56: Suppl 3 S431, 2007.

4. Ziv E, Rotem C, Miodovnik M, Ravid A, Koren R. Two modes of ERK activation by TNF in keratinocytes: Different cellular outcomes and bi-directional modulation by vitamin D. J Cell Biochem.104: 606-619, 2008. MEDLINE

5. Langberg M, Rotem C, Fenig E, Koren R, Ravid A. Vitamin D protects keratinocytes from deleterious effects of ionizing radiation. Brit. J. Dermatol. 160: 151-161, 2009. MEDLINE